Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 3 , Pages 214-224 , June 2006

Early recognition of neonatal hyperbilirubinemia and its emergent management

  • Hannah Smitherman

      Affiliations

    • Department of Pediatrics, Section of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA
    • Corresponding Author InformationCorresponding author. Baylor College of Medicine, 6621 Fannin St. MC 1-1481, Houston, TX 77030, USA. Tel.: +1 650 723 6621.
  • ,
  • Ann R. Stark

      Affiliations

    • Section of Neonatology, Baylor College of Medicine, Houston, TX, USA
  • ,
  • Vinod K. Bhutan

      Affiliations

    • Division of Neonatal and Developmental Medicine, Lucile Packard Children's Hospital and Stanford University, Stanford, CA, USA

References 

  1. Bhutani VK, Johnson LH, Shaprio SM. Kernicterus in sick and preterm infants (1999–2002): a need for an effective preventive approach. Semin Perinatol. October 2004;28(5):3129–5 [Review]
  2. Centers for Disease Control and Prevention. National center on birth defects and developmental disabilities: kernicterus. October 24, 2002. Available at http://www.cdc.gov/ncbddd/dd/kernicterus2.htm.
  3. Brown AK, Johnson L. Loss of concern about jaundice and the reemergence of Kernicterus in full-term infants in the era of managed care. In:  Fanaroff AA,  Klaus MH editor. The year book of neonatal and perinatal medicine. Philadelphia: Mosby Yearbook; 1996;p. xvii–xxviii
  4. A National Framework for Healthcare Quality Measurement and Reporting: A Consensus Report. National Quality Forum http://www.qualityforum.org.
  5. Maisels MJ, Gifford KL. Normal serum bilirubin level in the newborn and the effect of breastfeeding. Pediatrics. 1986;78:837–843
  6. American Academy of Pediatrics Practice Guidelines . Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 weeks or more of gestation. Pediatrics. 2004;114(1):297–316
  7. American Academy of Pediatrics Practice Parameter. Management of hyperbilirubinemia in the healthy term newborns. Pediatrics. 1994;94:558–565
  8. Mollen TJ, Scarfone R, Harris MC. Acute severe bilirubin encephalopathy in a newborn. Pediatric Emergency Care. September 2004;20(90):599–601
  9. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of pre-discharge hour-specific bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999;103:6–14
  10. Stevenson DK, Fanaroff A, Maisels J, et al. Prediction of hyperbilirubinemia in term and near-term newborn infants. Pediatrics. 2001;108:31–39
  11. Bhutani VK, Johnson LH, Keren R. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. Pediatr Clin North Am. August 2004;51(4):843–861vii
  12. Bhutani VK, Johnson LH, Maisels MJ, et al. Kernicterus: epidemiological strategies for its prevention through systems-based approaches. J Perinatol. 2004;24(10):650
  13. Bhutani VK, Johnson LH, Koren R. Treating acute bilirubin encephalopathy—before its too late. Contemp Pedso. 2005;22:57
  14. Kaplan M, Hercshel M, Hammerman C, Hoyer JD, Stevenson DK. Hyperbilirubinemia among African American, glucose-6-phosphate dehydrogenase deficient neonates. Pediatrics. August 2004;114(2):e213–e219
  15. Poland RL. Preventing kernicterus: almost there. J Pediatr. April 2002;140(4):396–403
  16. Bhutani VK. Neonatal hyperbilirubinemia and the potential risk of subtle neurological dysfunction. Pediatr Res. 2001;50:679
  17. Nakamura H, Yonetani M, Uetani Y, Funato M, Lee Y. Determination of serum unbound bilirubin for prediction of kernicterus in low birth weight infants. Acta Paediatr Jpn. 1992;34:642–647
  18. Funato M, Teraoka S, Tamai H, Shimada S, Nakamura H. Follow-up study of auditory brainstem evoked responses in hyperbilirubinemic newborns treated with exchange transfusion. Acta Paediatr Jpn. 1996;38:17–21
  19. Ahlfors CE. Criteria for exchange transfusion in jaundiced newborns. J Pediatr. 1994;93:488–494
  20. Mollison PL, Cutbush M. Diagnosis and treatment of hemolytic disease in the newborn. Concours Med. 18 April 1953;75(16):1445
  21. Jones MH, Sands R, Hyman CB, Sturgeon P, Koch FP. Longitudinal study of the incidence of central nervous system damage following erythroblastosis fetalis. Pediatrics. 1954;14:346
  22. Van Pragh R. Diagnosis of kernicterus in the neonatal period. Pediatrics. 1961;28:870–874
  23. Volpe JJ. Bilirubin and brain injury. In: Neurology of the newborn. 4th ed.. Philadelphia: WB Saunders; 2001;
  24. Johnson L, Brown AK, Bhutani VK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr. 2002;93:488–494
  25. Johnson L, Brown AK, Bhutani VK. BIND – a clinical score for bilirubin induced neurologic dysfunction in newborns. Pediatrics Suppl. 1999;104:746
  26. Perlstein M. Neurologic sequelae of erythroblastosis fetalis. Am J Dis Child. 1950;79:605–606
  27. Soorani-Lunsing I, Woltil A, Hadders-Algra M. Are moderate degrees of hyperbilirubinemia in healthy term neonates really safe for the brain?. Pediatr Res. 2001;50:701–705
  28. Forrester RM, Miller J. The dental changes associates with kernicterus. Arch Dis Child. 1953;30:224–231
  29. Byers RK, Paine RS, Crothers B. Extra pyramidal cerebral palsy with hearing loss following erythroblastosis. Pediatrics. 1955;15:248–254
  30. Ohlsson A, editor. Neonatal jaundice: continuing concern and need for research. Pediatr Res 2001;50:674.
  31. Maisels MD, Newman TB. Bilirubin and neurologic dysfunction – do we need to change what we are doing?. Pediatr Res. 2001;50:677
  32. Hintz S, Stevenson DK. Just when you thought is was safe. Pediatr Res. 2001;50:675–676
  33. Joint Commission on Accreditation of Healthcare Organizations. Sentinel Event Alert 18: Kernicterus Threatens Healthy Newborns; May 2, 2001. <https://www.jcaho.org/about+us/news+letters/sentinel+event+alert/sea-18.htm>.
  34. AAP Subcommittee on Neonatal Hyperbilirubinemia . Neonatal jaundice and kernicterus. Pediatrics. 2001;108:763–765
  35. Bhutani VK, Gourley G, Kreamer BL, Dalin C, Adler SA, Johnson L. Non-invasive measurement of total serum bilirubin in a multi-racial pre-discharge newborn population to assess the risk of severe hyperbilirubinemia. Pediatrics. 2000;106(2):e17
  36. Rubaltelli FF, Gourley GR, Loskamp N, et al. Transcutaneous bilirubin measurement: a multicenter evaluation of a new device. Pediatrics. 2001;107:1264–1271
  37. Ebbeson F, Rasmussen LM, Wimberly PD. A new transcutaneous bilirubinometer, Bilichek, used in the neonatal intensive care unit and the maternity ward. Acta Paediatr. 2002;91:203–211
  38. Slusher TM, Angyo IA, Bode-Thomas F, Akor F, Pam SD, Adetunii AA, et al. Transcutaneous bilirubin measurements and serum total bilirubin levels in indigenous African infants. Pediatrics. June 2004;113(6):1636–1641
  39. Engle WD, Jackson GL, Sendelbach D, Manning D, Frawley WH. Assessment of a transcutaneous device in the evaluation of neonatal hyperbilirubinemia in a primarily Hispanic population. Pediatrics. 2002;110:61–67
  40. Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C, Johnson LH. Noninvasive measurement of total serum bilirubin in a multiracial predischarge newborn population to assess the risk of severe hyperbilirubinemia. Pediatrics. 2000;106:E17
  41. Johnson L, Bhutani VK. Guidelines for management of the jaundiced term and near-term infant. Clin Perinatol. September 1998;25(3):555–574
  42. Bhutani VK, Johnson LH. Jaundice technologies: prediction of hyperbilirubinemia in term and near-term newborns. J Perinatal. 2001;21(Suppl. 1):S76–S82
  43. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a pre-discharge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. January 1999;103(1):6–14
  44. Bhutani VK, Johnson LH. Jaundice technologies: prediction of hyperbilirubinemia in term and near-term newborns. J Perinatol. 2001;21:S76–S82
  45. Garland JS, Alex C, Deacon JS, Raab K. Treatment of infants with indirect Hyperbilirubinemia. Readmission to birth hospital vs nonbirth hospital. Arch Pediatr Adolesc Med. 1994;148(12):13107–13121
  46. Brown AK, Damus K, Kim MH, King K, et al. Factors relating to readmission of term and near-term neonates in the first two weeks of life. Early Discharge Survey Group of the Health Professional Advisory Board of the Greater New York Chapter of the March of Dimes. J Perinat Med. 1999;27(4):263–275
  47. Suresh GK, Clark RE. Cost effectiveness of strategies that are intended to prevent kernicterus in newborn infants. Pediatrics. 2004;114(4):917–924
  48. Gourley GR, Kreamer B, Cohnen M, Kosorok MR. Neonatal jaundice and diet. Arch Pediatr Adolesc Med. February 1999;153(2):184–188
  49. Hansen TWR. Acute management of extreme neonatal jaundice – the potential benefits of intensified phototherapy and interruption of enterohepatic circulation. Acta Pediatr. 1997;86:843–846
  50. Johnson LH, Dalin C, Abbasi S, Weis C, Gerdes JS, Bhutani VK. The importance of measuring serum albumin in excessively hyperbilirubinemic infants. Pediatr Res. 2000;47:404A
  51. Alcock GS, Liley H. Immunoglobulin infusion for isoimmune haemolytic jaundice in neonates. Cochrane Database Syst Rev. 2002;3:CD003313
  52. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a pre-discharge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. January 1999;103(1):6–14
  53. Stevenson DK, Fanaroff A, Maisels J, et al. Prediction of hyperbilirubinemia in term and near-term newborn infants. Pediatrics. 2001;108:31–39
  54. Martinez JC, Garcia HO, Otheguy LE, Drummond GS, Kappas A. Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin. Pediatrics. January 1999;103(1):1–5
  55. Newman TB, Xiong B, Gonzales VM, Escobar GJ. Prediction and prevention of extreme neonatal hyperbilirubinemia in a mature health maintenance organization. Arch Pediatr Adolesc Med. 2000;154:1140–1147
  56. Newman TB, Klebanoff M. Neonatal hyperbilirubinemia and long-term outcome: Another look at the collaborative perinatal project. Pediatrics. 1993;92:651–657

PII: S1744-165X(06)00019-9

doi: 10.1016/j.siny.2006.02.002

Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 3 , Pages 214-224 , June 2006