Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 363-368, October 2006

Inflammation, brain damage and visual dysfunction in preterm infants

  • Olaf Dammann

      Affiliations

    • Perinatal Infectious Disease Epidemiology Unit, Departments of Gynecology and Obstetrics, and of Pediatric Pulmonology and Neonatology, Hannover Medical School, OE 6415, 30623 Hannover, Germany
    • Neuroepidemiology Unit, Department of Neurology, Children's Hospital and Harvard Medical School, 1 Autumn St, #720, Boston, MA 02215, USA
    • Corresponding Author InformationCorresponding author. Perinatal Infectious Disease Epidemiology Unit, Departments of Gynecology and Obstetrics, and of Pediatric Pulmonology and Neonatology, Hannover Medical School, OE 6415, 30623 Hannover, Germany. Tel.: +49 511 532 6825; fax: +49 511 532 6827.
    • ,
  • Alan Leviton

      Affiliations

    • Neuroepidemiology Unit, Department of Neurology, Children's Hospital and Harvard Medical School, 1 Autumn St, #720, Boston, MA 02215, USA

published online 03 April 2006.

Summary 

Antenatal intrauterine infection and the fetal inflammatory response appear to be important pathogenetic factors in preterm birth and subsequent neonatal disorders of the lung and brain. In this paper, we expand this concept to include visual dysfunction. Although present data tend to support our notion, we suggest that more experimental and epidemiological research is needed to elucidate mechanisms of infection/inflammation-induced damage to the eye and visual brain pathways of preterm infants.

Keywords: Inflammation, Brain, Vision, Infant, Premature

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PII: S1744-165X(06)00020-5

doi:10.1016/j.siny.2006.02.003

Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 363-368, October 2006

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