Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 363-368 , October 2006

Inflammation, brain damage and visual dysfunction in preterm infants

  • Olaf Dammann

      Affiliations

    • Perinatal Infectious Disease Epidemiology Unit, Departments of Gynecology and Obstetrics, and of Pediatric Pulmonology and Neonatology, Hannover Medical School, OE 6415, 30623 Hannover, Germany
    • Neuroepidemiology Unit, Department of Neurology, Children's Hospital and Harvard Medical School, 1 Autumn St, #720, Boston, MA 02215, USA
    • Corresponding Author InformationCorresponding author. Perinatal Infectious Disease Epidemiology Unit, Departments of Gynecology and Obstetrics, and of Pediatric Pulmonology and Neonatology, Hannover Medical School, OE 6415, 30623 Hannover, Germany. Tel.: +49 511 532 6825; fax: +49 511 532 6827.
  • ,
  • Alan Leviton

      Affiliations

    • Neuroepidemiology Unit, Department of Neurology, Children's Hospital and Harvard Medical School, 1 Autumn St, #720, Boston, MA 02215, USA

References 

  1. Leviton A. Preterm birth and cerebral palsy: is tumor necrosis factor the missing link?. Dev Med Child Neurol. 1993;35:553–558
  2. Dammann O, Leviton A. Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol. 1998;5:190–201
  3. Dammann O, Leviton A. Inflammatory brain damage in preterm newborns - dry numbers, wet lab, and causal inference. Early Hum Dev. 2004;79:1–15
  4. Dammann O, Leviton A, Bartels DB, Dammann CEL. Lung and brain damage in preterm newborns. Are they related? How? Why?. Biol Neonate. 2004;85:305–313
  5. Hoyt CS. Visual function in the brain-damaged child. Eye. 2003;17:369–384
  6. Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351:1985–1995
  7. Smith LE. Pathogenesis of retinopathy of prematurity. Growth Horm IGF Res. 2004;14(Suppl. A):S140–S144
  8. Repka MX. Ophthalmological problems of the premature infant. Ment Retard Dev Disabil Res Rev. 2002;8:249–257
  9. Leviton A, Paneth N. White matter damage in preterm newborns – an epidemiologic perspective. Early Hum Dev. 1990;24:1–22
  10. Leviton A, Gilles F. Ventriculomegaly, delayed myelination, white matter hypoplasia, and ‘periventricular’ leukomalacia: how are they related?. Pediatr Neurol. 1996;15:127–136
  11. Gilles FH, Murphy SF. Perinatal telencephalic leucoencephalopathy. J Neurol Neurosurg Psychiatry. 1969;32:404–413
  12. Counsell SJ, Allsop JM, Harrison MC, et al. Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality. Pediatrics. 2003;112:1–7
  13. Kuban KC, Allred EN, Dammann O, et al. Topography of cerebral white-matter disease of prematurity studied prospectively in 1607 very-low-birthweight infants. J Child Neurol. 2001;16:401–408
  14. Leviton A, Gilles FH. Morphologic abnormalities in human infant cerebral white matter related to gestational and postnatal age. Pediatr Res. 1974;8:718–720
  15. Inder TE, Wells SJ, Mogridge NB, Spencer C, Volpe JJ. Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr. 2003;143:171–179
  16. Fielder A, Quinn GE. Retinopathy of prematurity. In:  Taylor D,  Hoyt CS editor. Pediatric ophthalmology and strabismus. New York: Saunders; 2004;p. 506–530
  17. Goldenberg RL, Culhane JF. Infection as a cause of preterm birth. Clin Perinatol. 2003;30:677–700
  18. Leviton A, Gilles FH. Acquired perinatal leukoencephalopathy. Ann Neurol. 1984;16:1–8
  19. Adinolfi M. Infectious diseases in pregnancy, cytokines and neurological impairment: an hypothesis. Dev Med Child Neurol. 1993;35:549–553
  20. Dammann O, Leviton A. Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res. 1997;42:1–8
  21. Leviton A, Dammann O, Durum SK. The adaptive immune response in neonatal cerebral white matter damage. Ann Neurol. 2005;58:821–828
  22. Redline RW, Faye-Petersen O, Heller D, Qureshi F, Savell V, Vogler C. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol. 2003;6:435–448
  23. Smulian JC, Shen-Schwarz S, Vintzileos AM, Lake MF, Ananth CV. Clinical chorioamnionitis and histologic placental inflammation. Obstet Gynecol. 1999;94:1000–1005
  24. Wu YW. Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev. 2002;8:25–29
  25. Hagberg H, Wennerholm UB, Savman K. Sequelae of chorioamnionitis. Curr Opin Infect Dis. 2002;15:301–306
  26. Polam S, Koons A, Anwar M, Shen-Schwarz S, Hegyi T. Effect of chorioamnionitis on neurodevelopmental outcome in preterm infants. Arch Pediatr Adolesc Med. 2005;159:1032–1035
  27. Dammann O, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr. 2000;12:99–104
  28. Ogunyemi D, Murillo M, Jackson U, Hunter N, Alperson B. The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med. 2003;13:102–109
  29. Savitz DA, Blackmore CA, Thorp JM. Epidemiologic characteristics of preterm delivery: etiologic heterogeneity. Am J Obstet Gynecol. 1991;164:467–471
  30. Klebanoff MA, Shiono PH. Top down, bottom up and inside out: reflections on preterm birth. Paediatr Perinat Epidemiol. 1995;9:125–129
  31. Savitz DA, Dole N, Herring AH, et al. Should spontaneous and medically indicated preterm births be separated for studying aetiology?. Paediatr Perinat Epidemiol. 2005;19:97–105
  32. Hansen AR, Collins MH, Genest D, et al. Very low birthweight infant's placenta and its relation to pregnancy and fetal characteristics. Pediatr Dev Pathol. 2000;3:419–430
  33. Dammann O, Leviton A, Gappa M, Dammann CE. Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome. Br J Obstet Gynaecol. 2005;112(Suppl. 1):4–9
  34. Ancel PY, Marret S, Larroque B, et al. Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia? Results of the EPIPAGE cohort study. Am J Obstet Gynecol. 2005;193:178–184
  35. Collins M, Paneth N. Preeclampsia and cerebral palsy: are they related?. Dev Med Child Neurol. 1998;40:207–211
  36. Dammann O, Allred EN, Veelken N. Increased risk of spastic diplegia among very low birth weight children after preterm labor or prelabor rupture of membranes. J Pediatr. 1998;132:531–535
  37. Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed. 2005;90:F220–F224
  38. Faix RG, Donn SM. Association of septic shock caused by early-onset group B streptococcal sepsis and periventricular leukomalacia in the preterm infant. Pediatrics. 1985;76:415–419
  39. Vermeulen GM, Bruinse HW, Gerards LJ, de Vries LS. Perinatal risk factors for cranial ultrasound abnormalities in neonates born after spontaneous labour before 34 weeks. Eur J Obstet Gynecol Reprod Biol. 2001;94:290–295
  40. Mittal M, Dhanireddy R, Higgins RD. Candida sepsis and association with retinopathy of prematurity. Pediatrics. 1998;101:654–657
  41. Kim TI, Sohn J, Pi SY, Yoon YH. Postnatal risk factors of retinopathy of prematurity. Paediatr Perinat Epidemiol. 2004;18:130–134
  42. Liu PM, Fang PC, Huang CB, et al. Risk factors of retinopathy of prematurity in premature infants weighing less than 1600 g. Am J Perinatol. 2005;22:115–120
  43. Gupta VP, Dhaliwal U, Sharma R, Gupta P, Rohatgi J. Retinopathy of prematurity - risk factors. Ind J Pediatr. 2004;71:887–892
  44. Groneck P, Gotze-Speer B, Oppermann M, Eiffert H, Speer CP. Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics. 1994;93:712–718
  45. Brown DR, Biglan AW, Stretavsky MM. Retinopathy of prematurity: the relationship with intraventricular hemorrhage and bronchopulmonary dysplasia. J Pediatr Ophthalmol Strabismus. 1990;27:268–271
  46. Guzzetta A, Cioni G, Cowan F, Mercuri E. Visual disorders in children with brain lesions: 1. Maturation of visual function in infants with neonatal brain lesions: correlation with neuroimaging. Eur J Paediatr Neurol. 2001;5:107–114
  47. Kuban K, Sanocka U, Leviton A, et al. White matter disorders of prematurity: association with intraventricular hemorrhage and ventriculomegaly. J Pediatr. 1999;134:539–546
  48. Larroque B, Marret S, Ancel PY, et al. White matter damage and intraventricular hemorrhage in very preterm infants: the EPIPAGE study. J Pediatr. 2003;143:477–483
  49. Todd D, Cassell C, Kennedy J, John E. Retinopathy of prematurity in infants <32 weeks' gestation at birth in New South Wales in 1993 and 1994. J Paediatr Child Health. 1999;35:355–357
  50. Hameed B, Shyamanur K, Kotecha S, et al. Trends in the incidence of severe retinopathy of prematurity in a geographically defined population over a 10-year period. Pediatrics. 2004;113:1653–1657
  51. Gonçalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev. 2002;8:3–13
  52. Msall ME, Phelps DL, Hardy RJ, et al. Educational and social competencies at 8 years in children with threshold retinopathy of prematurity in the CRYO-ROP multicenter study. Pediatrics. 2004;113:790–799
  53. Deguchi K, Mizuguchi M, Takashima S. Immunohistochemical expression of tumor necrosis factor alpha in neonatal leukomalacia. Pediatr Neurol. 1996;14:13–16
  54. Deguchi K, Oguchi K, Takashima S. Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol. 1997;16:296–300
  55. Yoon BH, Romero R, Kim CJ, et al. High expression of tumor necrosis factor-alpha and interleukin-6 in periventricular leukomalacia. Am J Obstet Gynecol. 1997;177:406–411
  56. Kadhim H, Tabarki B, Verellen G, De Prez C, Rona AM, Sebire G. Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology. 2001;56:1278–1284
  57. Kadhim H, Tabarki B, De Prez C, Rona AM, Sebire G. Interleukin-2 in the pathogenesis of perinatal white matter damage. Neurology. 2002;58:1125–1128
  58. Kadhim H, Tabarki B, Prez CD, Sebire G. Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy?. Acta Neuropathol (Berl). 2003;105:209–216
  59. Folkerth RD, Keefe RJ, Haynes RL, Trachtenberg FL, Volpe JJ, Kinney HC. Interferon-gamma expression in periventricular leukomalacia in the human brain. Brain Pathol. 2004;14:265–274
  60. Bertsch T, Casarin W, Kretschmar M, et al. Protein S-100B: a serum marker for ischemic and infectious injury of cerebral tissue. Clin Chem Lab Med. 2001;39:319–323
  61. Garnier Y, Berger R, Alm S, et al. Systemic endotoxin administration results in increased S100B protein blood levels and periventricular brain white matter injury in the preterm fetal sheep. Eur J Obstet Gynecol Reprod Biol. 2006;124:15–22
  62. Park ES, Park CI, Choi KS, Choi IH, Shin JS. Over-expression of S100B protein in children with cerebral palsy or delayed development. Brain Dev. 2004;26:190–196
  63. Marlow N, Wolke D, Bracewell MA, Samara M. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med. 2005;352:9–19
  64. Hack M, Taylor HG, Drotar D, et al. Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. J Am Med Assoc. 2005;294:318–325
  65. Marlow N. Neurocognitive outcome after very preterm birth. Arch Dis Child Fetal Neonatal Ed. 2004;89:F224–F228
  66. SanGiovanni JP, Allred EN, Mayer DL, Stewart JE, Herrera MG, Leviton A. Reduced visual resolution acuity and cerebral white matter damage in very-low-birthweight infants. Dev Med Child Neurol. 2000;42:809–815
  67. Stiers P, van den Hout BM, Haers M, et al. The variety of visual perceptual impairments in pre-school children with perinatal brain damage. Brain Dev. 2001;23:333–348
  68. van den Hout BM, de Vries LS, Meiners LC, et al. Visual perceptual impairment in children at 5 years of age with perinatal haemorrhagic or ischaemic brain damage in relation to cerebral magnetic resonance imaging. Brain Dev. 2004;26:251–261
  69. Dammann O, Drescher J, Veelken N. Maternal fever at birth and non-verbal intelligence at age nine years in preterm infants. Dev Med Child Neurol. 2003;45:184–191
  70. Losch H, Dammann O. Impact of motor skills on cognitive test results in very-low-birthweight children. J Child Neurol. 2004;19:318–322
  71. Guzzetta A, Mercuri E, Cioni G. Visual disorders in children with brain lesions: 2. Visual impairment associated with cerebral palsy. Eur J Paediatr Neurol. 2001;5:115–119
  72. Buck GM, Msall ME, Schisterman EF, Lyon NR, Rogers BT. Extreme prematurity and school outcomes. Paediatr Perinat Epidemiol. 2000;14:324–331
  73. Mechoulam H, Pierce EA. Retinopathy of prematurity: molecular pathology and therapeutic strategies. Am J Pharmacogenomics. 2003;3:261–277
  74. Hellstrom A, Engstrom E, Hard AL, et al. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics. 2003;112:1016–1020
  75. Dammann O, Leviton A. Brain damage in preterm newborns: might enhancement of developmentally-regulated endogenous protection open a door for prevention?. Pediatrics. 1999;104:541–550

PII: S1744-165X(06)00020-5

doi: 10.1016/j.siny.2006.02.003

Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 363-368 , October 2006