Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 302-308 , October 2006

Inflammation and miscarriage

References 

  1. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today. 1996;17:138–146
  2. Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization. Fertil Steril. 2004;82:799–804
  3. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191–1193
  4. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal–fetal relationship: is pregnancy a TH2 phenomenon?. Immunol Today. 1993;14:353–356
  5. Yie J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of TNFα and IFNγ against primary human placental trophoblast. Placenta. 1994;15:819–835
  6. Ho S, Winkler-Lowen B, Morrish B, Dakour J, Li H, Guilbert LJ. The role of Bcl-2 expression in EGF inhibition of TNFα/IFNγ induced villous trophoblast apoptosis. Placenta. 1999;20:423–430
  7. Ashkar AA, Croy BA. Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy. Semin Immunol. 2001;13:235–241
  8. Bates MD, Quenby S, Takawuwa K, Johnson PM, Vince GM. Aberrant cytokine production by peripheral blood mononuclear cells in recurrent miscarriage?. Hum Reprod. 2002;17:2439–2444
  9. Sacks GP, Redman CW, Sargent IL. Monocytes are primed to produce the Th1 cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol. 2003;131:490–497
  10. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptor in women with pre-eclampsia. BJOG. 1995;102:20–25
  11. Steward CLK, Kasper P, Brunet IJ, Bhatt H, Gadi I, Kontgen F, et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 1992;359:76–79
  12. Guimond MJ, Wang B, Croy BA. Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer-deficient Tg epsilon 26 mice. J Exp Med. 1998;187:217–223
  13. Murphy SP, Fast LD, Hanna NN, Sharma S. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J Immunol. 2005;175:4084–4090
  14. Hill JA, Polgar K, Anderson DJ. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA. 1995;273:1933–1936
  15. Lachapelle MH, Miron P, Hemmings R, Roy DC. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol. 1996;156:4027–4034
  16. Kruse C, Varming K, Christiansen OB. Prospective, serial investigations of the in-vitro lymphocyte cytokine production, CD62L expression and proliferative response to microbial antigens in women with recurrent miscarriage. Hum Reprod. 2003;18:2465–2472
  17. Yamamoto T, Takahashi Y, Kase N, Mori H. Role of decidual natural killer (NK) cells in patients with missed abortion: differences between cases with normal and abnormal chromosome. Clin Exp Immunol. 1999;116:449–452
  18. Yamada H, Kato EH, Kobashi G, Ebina Y, Shimada S, Morikawa M, et al. High NK cell activity in early pregnancy correlates with subsequent abortion with normal chromosomes in women with recurrent abortion. Am J Reprod Immunol. 2001;46:132–136
  19. Quack KC, Vassiliadou N, Pudney J, Anderson DJ, Hill JA. Leukocyte activation in the decidua of chromosomally normal and abnormal fetuses from women with recurrent abortion. Hum Reprod. 2001;16:949–955
  20. von Wolff M, Thaler CJ, Strowizki T, Broome J, Stolz W, Tabibzadeh S. Regulated expression of cytokines in human endometrium throughout the menstrual cycle; dysregulation in habitual abortion. Mol Hum Reprod. 2000;6:627–634
  21. Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AIF, Li TC. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update. 2003;9:163–174
  22. Michel MZ, Underwood JL, Clark DA, Mowbray JF, Beard RW. Histologic and immunological study of uterine biopsy tissue of women with incipient abortion. Am J Obstet Gynecol. 1989;161:409–414
  23. Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med. 1998;4:1020–1024
  24. Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Immunobiology. 2001;97:3146–3151
  25. Daher S, Shulzhenko N, Morgun A, Mattar R, Rampim GF, Camano L, et al. Associations between cytokine gene polymorphism and recurrent pregnancy loss. J Reprod Immunol. 2003;58:69–77
  26. von Linsingen R, Bompeixe EP, Bicalho Mda G. A case–control study in IL6 and TGFB1 gene polymorphisms and recurrent spontaneous abortion in southern Brazilian patients. Am J Reprod Immunol. 2005;53:94–99
  27. Saijo Y, Sata F, Yamada H, Kondo T, Kato EH, Kishi R. Single nucleotide polymorphisms in the promoter region of the interleukin-6 gene and the risk of recurrent pregnancy loss in Japanese women. Fertil Steril. 2004;81:374–378
  28. Prigoshin N, Tambutti M, Larriba J, Gogorza S, Testa R. Cytokine gene polymorphism in recurrent pregnancy loss of unknown cause. Am J Reprod Immunol. 2004;52:36–41
  29. Pietrowski D, Bettendorf H, Keck C, Burkle B, Unfried G, Riener EK, et al. Lack of association between TNF-alpha gene polymorphisms and recurrent pregnancy loss in Caucasian women. J Reprod Immunol. 2004;61:51–58
  30. Costeas PA, Koumouli A, Giantsiou-Kyriakou A, Papaloizou A, Koumas L. Th1/Th3 cytokine genotypes are associated with pregnancy loss. Hum Immunol. 2004;65:135–141
  31. Wang ZC, Yunis EJ, De los Santos MJ, Xiao L, Anderson DJ, Hill JA. T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 2002;3:38–42
  32. Perni SC, Vardhana S, Tuttle SL, Kalish RB, Chasen ST, Witkin SS. Fetal interleukin-1 receptor antagonist gene polymorphism, intra-amniotic interleukin-1beta levels, and history of spontaneous abortion. Am J Obstet Gynecol. 2004;191:1318–1323
  33. Hefler LA, Tempfer CB, Unfried G, Schneeberger C, Lessl K, Nagele F, et al. A polymorphism of the interleukin-1 beta gene and idiopathic recurrent miscarriage. Fertil Steril. 2001;76:377–379
  34. Hefler LA, Tempfer CB, Bashford MT, Unfried G, Zeillinger R, Schneeberger C, et al. Polymorphisms of the angiotensin gene, the endothelial nitric oxide synthase gene, and the interleukin-1 beta gene promoter in women with idiopathic recurrent miscarriage. Mol Hum Reprod. 2002;8:95–100
  35. Linjawi S, Li TC, Laird S, Blakemore A. Interleukin-1 receptor antagonist and interleukin-1 beta polymorphisms in women with recurrent miscarriage. Fertil Steril. 2005;83:1549–1552
  36. Jack DL, Read RC, Tenner AJ, Frosch M, Turner MW, Klein NJ. Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis Serogroup B. J Infect Dis. 2001;184:1152–1162
  37. Ogden CA, deCathelineu A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, et al. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med. 2001;194:781–795
  38. Borzychowski AM, Croy BA, Chan WL, Redman CWG, Sargent IL. Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells. Eur J Immunol. 2005;35:3054–3063
  39. Kilpatrick DC, Bevan BH, Liston WA. Association between mannan-binding protein deficiency and recurrent miscarriage. Hum Reprod. 1995;10:2501–2505
  40. Kruse C, Rosgaard A, Steffensen R, Varming K, Jensenius JC, Christiansen OB. Low serum level of mannan-binding lectin is a determinant for pregnancy outcome in women with recurrent spontaneous abortion. Am J Obstet Gynecol. 2002;187:1313–1320
  41. Van der Meer A, Lukassen HGM, van Lierop MJC, Wijnands F, Mosselman S, Braat DDM, et al. Membrane-bound HLA-G activates proliferation and interferon-γ production by uterine natural killer cells. Mol Hum Reprod. 2004;10:189–195
  42. Maejima M, Fujii T, Kozuma S, Okai T, Shibata Y, Taketani Y. Presence of HLA-G-expressing cells modulates the ability of peripheral blood mononuclear cells to release cytokines. Am J Reprod Immunol. 1997;38:75–78
  43. Kapasi K, Albert SE, Yie SM, Zavazava N, Libranch CL. HLA-G has a concentration-dependent effect on the generation of an allo-CTL response. Immunology. 2000;101:191–200
  44. Hviid TV, Rizzo R, Christiansen OB, Melchiorri L, Lindhard A, Baricordi OR. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. Immunogenetics. 2004;56:135–141
  45. Hviid TV, Hylenius S, Lindhard A, Christiansen OB. Association between human leukocyte antigen-G genotype and success of in-vitro fertilization and pregnancy outcome. Tissue Antigens. 2004;64:66–69
  46. Hviid TV, Christiansen OB. Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G – possible implications for human reproduction and autoimmune disease. Hum Immunol. 2005;66:688–699
  47. Kruse C, Steffensen R, Varming K, Christiansen OB. A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB103 is associated with recurrent miscarriage. Hum Reprod. 2004;19:1215–1221
  48. Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, et al. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononucelar cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol. 1993;23:224–231
  49. Laskin CA, Bombardier C, Hannah ME, Mandel FP, Ritchie JW, Farewell V, et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med. 1997;337:148–153
  50. Christiansen OB, Pedersen B, Rosgaard A, Husth M. A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: evidence for a therapeutic effect in women with secondary recurrent miscarriage. Hum Reprod. 2002;17:809–816
  51. Laskarin G, Tokmadzic VS, Strbo N, Bogovic T, Szekeres-Bartho J, Randic L, et al. Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am J Reprod Immunol. 2002;48:201–209
  52. Sedlmayr P, Blaschitz A, Wintersteiger R, Semlitsch M, Hammer A, MacKenzie CR, et al. Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta. Mol Hum Reprod. 2002;8:385–391
  53. ∗ The most important references are indicated with an asterisks.

PII: S1744-165X(06)00031-X

doi: 10.1016/j.siny.2006.03.001

Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 302-308 , October 2006