Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 317-326 , October 2006

Inflammation in preterm and term labour and delivery

  • Roberto Romero

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
    • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA
    • Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA
    • Corresponding Author InformationCorresponding author. Perinatology Research Branch, NICHD, NIH, DHHS, Hutzel Women's Hospital – Box #4, 3990 John R., Detroit, MI 48201, USA. Tel.: +1 313 993 2700; fax: +1 313 993 2694.
    • ,
  • Jimmy Espinoza

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    • ,
  • Luís F. Gonçalves

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    • ,
  • Juan Pedro Kusanovic

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
    • ,
  • Lara A. Friel

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    • ,
  • Jyh Kae Nien

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA

References 

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  2. Haddad R, Tromp G, Kuivaniemi H, Chaiworapongsa T, Kim YM, Romero R. Spontaneous labor at term is characterized by a genomic signature of acute inflammation in the chorioamniotic membranes but not in the systemic circulation. Am J Obstet Gynecol. 2004;191(6):S138
  3. Yoon BH, Romero R, Moon JB, Shim SS, Kim M, Kim G, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2001;185(5):1130–1136
  4. Yoon BH, Romero R, Park JS, Kim M, Oh SY, Kim CJ, et al. The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol. 2000;183(5):1124–1129
  5. Romero R, Sirtori M, Oyarzun E, Avila C, Mazor M, Callahan R, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol. 1989;161(3):817–824
  6. Goncalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev. 2002;8(1):3–13
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  8. Fidel PL, Romero R, Wolf N, Cutright J, Ramirez M, Araneda H, et al. Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice. Am J Obstet Gynecol. 1994;170(5 Pt 1):1467–1475
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  10. Elovitz MA, Mrinalini C. Animal models of preterm birth. Trends Endocrinol Metab. 2004;15(10):479–487
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  12. Romero R, Munoz H, Gomez R, Sherer DM, Ghezzi F, Gibbs RS, et al. Two thirds of spontaneous abortion/fetal deaths after genetic amniocentesis are the result of a pre-existing sub-clinical inflammatory process of the amniotic cavity. Am J Obstet Gynecol. 1995;172:S261
  13. Fidel P, Ghezzi F, Romero R, Chaiworapongsa T, Espinoza J, Cutright J, et al. The effect of antibiotic therapy on intrauterine infection-induced preterm parturition in rabbits. J Matern Fetal Neonatal Med. 2003;14(1):57–64
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  20. Yoon BH, Romero R, Lim JH, Shim SS, Hong JS, Shim JY, et al. The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor. Am J Obstet Gynecol. 2003;189(4):919–924
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  23. Romero R, Mazor M, Morrotti R, Avila C, Oyarzun E, Insunza A, et al. Infection and labor. VII. Microbial invasion of the amniotic cavity in spontaneous rupture of membranes at term. Am J Obstet Gynecol. 1992;166(1 Pt 1):129–133
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PII: S1744-165X(06)00054-0

doi: 10.1016/j.siny.2006.05.001

Seminars in Fetal & Neonatal Medicine
Volume 11, Issue 5 , Pages 317-326 , October 2006

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