Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 2 , Pages 143-150, April 2007

Impact of maternal substance use during pregnancy on childhood outcome

  • Seetha Shankaran

      Affiliations

    • Wayne State University School of Medicine, Detroit, MI, USA
    • Neonatal–Perinatal Medicine, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, MI, USA
    • Corresponding Author InformationCorresponding author. Children's Hospital of Michigan, Division Neonatology, 3901 Beaubien, Detroit, MI 48201, USA. Tel.: +1 313 745 1436; fax: +1 313 745 5867.
  • ,
  • Barry M. Lester

      Affiliations

    • Brown Medical School, Women & Infants Hospital of Rhode Island, Providence, RI, USA
  • ,
  • Abhik Das

      Affiliations

    • Research Triangle Institute, Rockville, MD, USA
  • ,
  • Charles R. Bauer

      Affiliations

    • Department of Pediatrics, University of Miami School of Medicine, Miami, FL, USA
  • ,
  • Henrietta S. Bada

      Affiliations

    • University of Kentucky, Lexington, KY, USA
  • ,
  • Linda Lagasse

      Affiliations

    • Department of Pediatrics, Brown Medical School, Providence, RI, USA
  • ,
  • Rosemary Higgins

      Affiliations

    • Center for Developmental Biology and Perinatal Medicine, NICHD, National Institute Health, Bethesda, MD, USA

published online 22 February 2007.

Summary 

The impact of maternal substance abuse is reflected in the 2002–2003 National Survey on Drug Use and Health. Among pregnant women in the 15–44 age group, 4.3%, 18% and 9.8% used illicit drugs, tobacco and alcohol, respectively. Maternal pregnancy complications following substance use include increases in sexually transmitted disorders, placental abruption and HIV-positive status. Effects on the neonate include a decrease in growth parameters and increases in central nervous system and autonomic nervous system signs and in referrals to child protective agencies. In childhood, behavioral and cognitive effects are seen after prenatal cocaine exposure; tobacco and alcohol have separate and specific effects. The ongoing use of alcohol and tobacco by the caretaker affects childhood behavior. Therefore, efforts should be made to prevent and treat behavioral problems as well as to limit the onset of drug use by adolescent children born to women who use drugs during pregnancy.

Keywords: Alcohol, Child medicine, Cocaine, Neonatal, Neurobehavioral outcome, Polydrug use, Tobacco

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PII: S1744-165X(07)00002-9

doi:10.1016/j.siny.2007.01.002

Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 2 , Pages 143-150, April 2007