Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 2 , Pages 143-150 , April 2007

Impact of maternal substance use during pregnancy on childhood outcome

  • Seetha Shankaran

      Affiliations

    • Wayne State University School of Medicine, Detroit, MI, USA
    • Neonatal–Perinatal Medicine, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, MI, USA
    • Corresponding Author InformationCorresponding author. Children's Hospital of Michigan, Division Neonatology, 3901 Beaubien, Detroit, MI 48201, USA. Tel.: +1 313 745 1436; fax: +1 313 745 5867.
    • ,
  • Barry M. Lester

      Affiliations

    • Brown Medical School, Women & Infants Hospital of Rhode Island, Providence, RI, USA
    • ,
  • Abhik Das

      Affiliations

    • Research Triangle Institute, Rockville, MD, USA
    • ,
  • Charles R. Bauer

      Affiliations

    • Department of Pediatrics, University of Miami School of Medicine, Miami, FL, USA
    • ,
  • Henrietta S. Bada

      Affiliations

    • University of Kentucky, Lexington, KY, USA
    • ,
  • Linda Lagasse

      Affiliations

    • Department of Pediatrics, Brown Medical School, Providence, RI, USA
    • ,
  • Rosemary Higgins

      Affiliations

    • Center for Developmental Biology and Perinatal Medicine, NICHD, National Institute Health, Bethesda, MD, USA

References 

  1. Substance Abuse Mental Health Services Administration. Office of Applied Studies. National household survey on drug abuse 2002, 2003 and 2004. 2004.
  2. Behnke M, Eyler FD, Garvan CW, Wobie K. The search for congenital malformations in newborns with fetal cocaine exposure. Pediatrics. 2001;107:[5/e74]
  3. Frank DA, McCarten KM, Robson CD, Mirochnick M, Cabral H, Park H, et al. Level of in-utero cocaine exposure and neonatal ultrasound findings. Pediatrics. 1999;104:1101–1105
  4. Richardson GA, Hamel SC, Goldschmidt L, Day NL. Growth of infants prenatally exposed to cocaine/crack: comparison of a prenatal care and no prenatal care sample. Pediatrics. 1999;104(2):e18
  5. Eyler FD, Behnke M, Conlon M, Woods NS, Wobie K. Birth outcome from a prospective, matched study of prenatal crack/cocaine use: 1. Interactive and dose effects on health and growth. Pediatrics. 1998;101(2):229–237
  6. Bateman DA, Chiriboga CA. Dose-response effects of cocaine on newborn head circumference. Pediatrics. 2000;106(3):e33
  7. Lester BM, LaGasse L, Freier C, Brunner S. Human studies of cocaine exposed infants. In: Behavioral studies of drug-exposed offspring: methodological issues in human and animal research. NIDA Monograph Series. vol. 164:Rochville, MD: NIDA; 1996;p. 175–210
  8. Lester BM, LaGasse L, Brunner S. Data base of studies on prenatal cocaine exposure and child outcome. J Drug Issues. 1997;27(2):487–499
  9. Lester BM, ElSohly M, Wright LL, Smeriglio VL, Verter J, Bauer CR, et al. The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics. 2001;107:309–317
  10. Bauer CR, Shankaran S, Bada HS, Lester BM, Wright LL, Krause-Steinrauf H, et al. The Maternal Lifestyle Study (MLS): drug exposure during pregnancy and short-term maternal outcomes. Am J Obstet Gynecol. 2002;186:487–495
  11. Bauer CR, Langer JC, Shankaran S, Bada HS, Lester B, Wright LL, et al. Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med. 2005;159:824–834
  12. Bada HS, Bauer CR, Shankaran S, Lester B, Wright LL, Das A, et al. Central and autonomic nervous systems (CNS/ANS) signs associated with in-utero cocaine/opiate exposure. Arch Dis Child Neonatal Ed. 2002;87:F106–F112
  13. Bada HS, Das A, Bauer CR, Shankaran S, Lester B, Wright LL, et al. Gestational cocaine exposure and intrauterine growth (Maternal Lifestyle Study). Obstet Gynecol. 2002;100:916–924
  14. Shankaran S, Das A, Bauer CR, Bada HS, Lester B, Wright L, et al. Association between patterns of maternal substance use and infant birth weight, length and head circumference. Pediatrics. 2004;114:e226–e234
  15. Bada HS, Das A, Bauer CR, Shankaran S, Lester B, Gard CC, et al. Low birth weight and preterm births: etiologic fraction attributable to prenatal drug exposure. J Perinatol. 2005;25:631–637
  16. Shankaran S, Das A, Bauer CR, Bada H, Lester B, Wright L, et al. Cocaine exposure (EXP) and small for gestational age status (SGA) at birth: effects on growth at 6-years. The Maternal Lifestyle Study. Pediatr Res. 2002;51:326A
  17. Needleman R, Frank DA, Cabral H, Mirochnick M, Kwon C, Zuckerman B. Blood pressure in children exposed prenatally to cocaine. Clin Pediatr. 1998;37:659–664
  18. Horn PT. Persistent hypertension after prenatal cocaine exposure. J Pediatr. 1992;121:288–291
  19. Shankaran S, Das A, Bauer CR, Bada H, Lester B, Wright L, et al. Fetal origin of childhood disease: intrauterine growth restriction in term infants and risk for hypertension at 6 years. Arch Pediatr Adolesc Med. 2006;160:977–981
  20. Joyce T, Racine AD, McCalla S, Wehbeh H. The impact of prenatal exposure to cocaine on newborn costs and length of stay. Health Serv Res. 1995;30(2):341–358
  21. Behnke M, Eyler FD, Conlon M, Casanova OQ, Woods NS. How fetal cocaine exposure increases neonatal hospital costs. Pediatrics. 1997;99:204–208
  22. Shankaran S, Bauer CR, Bada HS, Lester B, Wright LL, Das A. Health-care utilization among mothers and infants following cocaine exposure. J Perinatol. 2003;23:361–367
  23. Miller LC, Lester BM, Seifer R, Lagasse LL, Bauer CR, Shankaran S, et al. Predictors of motor development in children prenatally exposed to cocaine. Neurotoxicology. 2005;27(2):213–220
  24. Hertzig ME. Neurological ‘soft’ signs in low-birthweight children. Dev Med Child Neurol. 1981;23:778–791
  25. Pine DS, Scott MR, Busner C, Davies M, Fried JA, Parides M, et al. Psychometrics of neurological soft signs. J Am Acad Child Adolesc Psychiatry. 1996;35:509–515
  26. Pine DS, Wasserman GA, Fried JE, Parides M, Shaffer D. Neurological soft signs: one-year stability and relationship to psychiatric symptoms in boys. J Am Acad Child Adolesc Psychiatry. 1997;36:1579–1586
  27. Breslau N, Chilcoat HD, Johnson EO, Andreski P, Lucia VC. Neurologic soft signs and low birthweight: their association and neuropsychiatric implications. Biol Psychiatry. 2000;47:71–79
  28. Shankaran S, Langer J, Bauer C, Bada H, Lester B, Poole K, et al. Neurological correlates at 7years of age of intrauterine exposure to cocaine and alcohol. Pediatr Res. 2004;55:492A
  29. Lester BM, Tronick EZ, LaGasse L, Seifer R, Bauer CR, Shankaran S, et al. The Maternal Lifestyle Study (MLS): effects of substance exposure during pregnancy on neurodevelopmental outcome in one-month old infants. Pediatrics. 2002;110:1182–1192
  30. Lester BM, LaGasse L, Seifer R, Tronick EZ, Bauer CR, Shankaran S, et al. The Maternal Lifestyle Study (MLS): effects of substance and/or opiate exposure during pregnancy on auditory brain response at one month. J Pediatr. 2003;142:279–285
  31. Messinger DS, Bauer CR, Das A, Seifer R, Lester BM, LaGasse LL, et al. The Maternal Lifestyle Study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of age. Pediatrics. 2004;113:1677–1685
  32. Bada H, Das A, Bauer CR, Shankaran S, Lester B, LaGasse L, et al. Impact of prenatal cocaine exposure on child behavior problems through school age. Pediatrics (in press).
  33. Lester BM, Lieu J, LaGasse L, Seifer R, Bauer CR, Shankaran S, et al. Neurobiological dysregulation model of prenatal cocaine exposure and behavior problems at age 7. Pediatr Acad Soc (proceeds of meeting). 2005;57:1625
  34. Seifer R, LaGasse LL, Lester B, Bauer CR, Shankaran S, Bada HS, et al. Attachment status in children prenatally exposed to cocaine and other substances. Child Dev. 2004;75(3):850–868
  35. Lester BM, Das A, LaGasse , Seifer R, Bauer CR, Shankaran S, et al. Prenatal cocaine exposure and 7-year outcome: IQ and special education. Pediatr Res. 2003;53:534A
  36. Wilson GS, Desmond MM, Verniaud WM. Early development of infants of heroin-addicted mothers. Am J Dis Child. 1973;126(4):457–462
  37. Zelson C, Rubio E, Wasserman E. Neonatal narcotic addiction: 10 year observation. Pediatrics. 1971;48(2):178–189
  38. Ostrea EM, Chavez CJ, Strauss ME. A study of factors that influence the severity of neonatal narcotic withdrawal. J Pediatr. 1976;88(4 Pt 1):642–645
  39. Bauer CR. Long term outcome following prenatal opiate exposure. Pediatr Acad Soc (personal communication).
  40. Harrell . Regression modeling strategies. New York: Springer; 2001;
  41. Das A, Poole WK, Bada H. A repeated measures approach for simultaneous modeling of multiple neurobehavioral outcomes in newborns exposed to cocaine in utero. Am J Epidemiol. 2004;159(2):891–899
  42. Raghunathan TE, Lepkowski JM, VanHoewyk J, et al. A multivariate technique for multiply imputing missing values using a sequence of regression models. Surv Methodol. 2001;27(1):85–95

PII: S1744-165X(07)00002-9

doi: 10.1016/j.siny.2007.01.002

Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 2 , Pages 143-150 , April 2007

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