Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 4 , Pages 303-310 , August 2007

Hypothermia

References 

  1. Siesjo BK, Katsura K, Kristian T. The biochemical basis of cerebral ischemic damage. J Neurosurg Anesthesiol. 1995;7:47–52
  2. Siesjo BK. Cell damage in the brain: a speculative synthesis. Acta Psychiatr Scand Suppl. 1984;313:57–91
  3. Blumberg RM, Cady EB, Wigglesworth JS, McKenzie JE, Edwards AD. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain. Exp Brain Res. 1997;113:130–137
  4. Amess PN, Penrice J, Wylezinska M, Lorek A, Townsend J. Wyatt JS et al. Early brain proton magnetic resonance spectroscopy and neonatal neurology related to neurodevelopmental outcome at 1 year in term infants after presumed hypoxic-ischaemic brain injury. Dev Med Child Neurol. 1999;41:436–445
  5. Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, et al. Delayed (‘secondary’) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1994;36:699–706
  6. Edwards AD, Azzopardi DV. Perinatal hypoxia-ischemia and brain injury. Pediatr Res. 2000;47:431–432
  7. Azzopardi D, Wyatt JS, Cady EB, Delpy DT, Baudin J, Stewart AL, et al. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1989;25:445–451
  8. Robertson NJ, Cox IJ, Cowan FM, Counsell SJ, Azzopardi D, Edwards AD. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res. 1999;46:287–296
  9. Roth SC, Edwards AD, Cady EB, Delpy DT, Wyatt JS, Azzopardi D, et al. Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year. Dev Med Child Neurol. 1992;34:285–295
  10. Siesjo BK, Elmer E, Janelidze S, Keep M, Kristian T, Ouyang YB, et al. Role and mechanisms of secondary mitochondrial failure. Acta Neurochir Suppl (Wien). 1999;73:7–13
  11. Siesjo BK, Katsura K, Zhao Q, Folbergrova J, Pahlmark K, Siesjo P, et al. Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma. 1995;12:943–956
  12. Taylor DL, Edwards AD, Mehmet H. Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol. 1999;9:93–117
  13. Northington FJ, Ferriero DM, Graham EM, Traystman RJ, Martin LJ. Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol Dis. 2001;8:207–219
  14. Smith SL, Hall ED. Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J Neurotrauma. 1996;13:1–9
  15. Busto R, Globus MY, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke. 1989;20:904–910
  16. Nakashima K, Todd MM. Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke. 1996;27:913–918
  17. Globus MY, Alonso O, Dietrich WD, Busto R, Ginsberg MD. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem. 1995;65:1704–1711
  18. Akisu M, Huseyinov A, Yalaz M, Cetin H, Kultursay N. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. Prostaglandins Leukotrienes Essent Fatty Acids. 2003;69:45–50
  19. Qing M, Nimmesgern A, Heinrich PC, Schumacher K, Vazquez-Jimenez JF, Hess J, et al. Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway. Crit Care Med. 2003;31:2769–2775
  20. Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab. 2003;23:513–530
  21. Amess PN, Penrice J, Cady EB, Lorek A, Wylezinska M, Cooper CE, et al. Mild hypothermia after severe transient hypoxia-ischemia reduces the delayed rise in cerebral lactate in the newborn piglet. Pediatr Res. 1997;41:803–808
  22. Bona E, Hagberg H, Loberg EM, Bagenholm R, Thoresen M. Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short- and long-term outcome. Pediatr Res. 1998;43:738–745
  23. Gunn AJ, Gunn TR, Gunning MI, Williams CE, Gluckman PD. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics. 1998;102:1098–1106
  24. Edwards AD, Yue X, Squier MV, Thoresen M, Cady EB, Penrice J, et al. Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun. 1995;217:1193–1199
  25. Xu L, Yenari MA, Steinberg GK, Giffard RG. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab. 2002;22:21–28
  26. Zhu C, Wang X, Cheng X, Qiu L, Xu F, Simbruner G, et al. Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia. Brain Res. 2004;996:67–75
  27. Zhang Z, Sobel RA, Cheng D, Steinberg GK, Yenari MA. Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia. Brain Res Mol Brain Res. 2001;95:75–85
  28. Tomimatsu T, Fukuda H, Endoh M, Mu J, Kanagawa T, Hosono T, et al. Long-term neuroprotective effects of hypothermia on neonatal hypoxic-ischemic brain injury in rats, assessed by auditory brainstem response. Pediatr Res. 2003;53:57–61
  29. Colbourne F, Corbett D, Zhao Z, Yang J, Buchan AM. Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model. J Cereb Blood Flow Metab. 2000;20:1702–1708
  30. MacLellan CL, Girgis J, Colbourne F. Delayed onset of prolonged hypothermia improves outcome after intracerebral hemorrhage in rats. J Cereb Blood Flow Metab. 2004;24:432–440
  31. Taylor DL, Mehmet H, Cady EB, Edwards AD. Improved neuroprotection with hypothermia delayed by 6 h following cerebral hypoxia-ischemia in the 14-day-old rat. Pediatr Res. 2002;51:13–19
  32. Tooley JR, Satas S, Porter H, Silver IA, Thoresen M. Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective. Ann Neurol. 2003;53:65–72
  33. Gunn AJ, Bennet L, Gunning MI, Gluckman PD, Gunn TR. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res. 1999;46:274–280
  34. Thoresen M, Satas S, Loberg EM, Whitelaw A, Acolet D, Lindgren C, et al. Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective. Pediatr Res. 2001;50:405–411
  35. Clifton GL, Choi SC, Miller ER, Levin HS, Smith KR, Muizelaar JP, et al. Intercenter variance in clinical trials of head trauma—experience of the National Acute Brain Injury Study: Hypothermia. J Neurosurg. 2001;95:751–755
  36. Henderson WR, Dhingra VK, Chittock DR, Fenwick JC, Ronco JJ. Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis. Intensive Care Med. 2003;29:1637–1644
  37. McIntyre LA, Fergusson DA, Hebert PC, Moher D, Hutchison JS. Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA. 2003;289:2992–2999
  38. Hypothermia after Cardiac Arrest Study Group . Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–556
  39. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–563
  40. Nolan JP, Morley PT, Hoek TL, Hickey RW. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resus. 2003;57:231–235
  41. Speer M, Perlman JM. Modest hypothermia as a neuroprotective strategy in high-risk term infants. Clin Perinatol. 2006;33:169–182[ix]
  42. Edwards AD, Azzopardi DV. Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal. 2006;91:F127–F131
  43. Higgins RD, Raju TN, Perlman J, Azzopardi DV, Blackmon LR, Clark RH, et al. Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr. 2006;148:170–175
  44. Higgins RD. Hypoxic ischemic encephalopathy and hypothermia: a critical look. Obstet Gynecol. 2005;106:1385–1387
  45. Gunn AJ, Battin M, Gluckman PD, Gunn TR, Bennet L. Therapeutic hypothermia: from lab to NICU. J Perinat Med. 2005;33:340–346
  46. Thoresen M, Whitelaw A. Therapeutic hypothermia for hypoxic-ischaemic encephalopathy in the newborn infant. Curr Opin Neurol. 2005;18:111–116
  47. Wyatt JS, Robertson NJ. Time for a cool head-neuroprotection becomes a reality. Early Hum Dev. 2005;81:5–11
  48. Barks J. Neonatal hypothermia: What are we waiting for? Online. Available at: http://www.nicuniversity.org/lectures.asp [last accessed 2005].
  49. Thoresen M, Simmonds M, Satas S, Tooley J, Silver IA. Effective selective head cooling during posthypoxic hypothermia in newborn piglets. Pediatr Res. 2001;49:594–599
  50. Van Leeuwen GM, Hand JW, Lagendijk JJ, Azzopardi DV, Edwards AD. Numerical modeling of temperature distributions within the neonatal head. Pediatr Res. 2000;48:351–356
  51. Azzopardi D, Robertson NJ, Cowan FM, Rutherford MA, Rampling M, Edwards AD. Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. Pediatrics. 2000;106:684–694
  52. Thoresen M, Whitelaw A. Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics. 2000;106:92–99
  53. Zhou WH, Shao XM, Cao Y, Chen C, Zhang X. Safety study of hypothermia for the treatmnet of hypoxic-ischaemic brain damage in term neonates. Acta Pharmacol Sin. October, 2002;23:64–68
  54. Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, et al. Moderate hypothermia in neonatal encephalopathy: Safety outcomes. Pediatr Neurol. 2005;32:18–24
  55. Gunn TR, Wilson NJ, Aftimos S, Gunn AJ. Brain hypothermia and QT interval. Pediatrics. 1999;103:1079
  56. Horan M, Edwards AD, Firmin RK, Ablett T, Rawson H, Field D. The effect of temperature on the QTc interval in the newborn infant receiving extracorporeal membrane oxygenation (ECMO). Early Hum Dev 2006 July 10 [Epub ahead of print].
  57. Rutherford MA, Azzopardi D, Whitelaw A, Cowan F, Renowden S, Edwards AD, et al. Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy. Pediatrics. 2005;116:1001–1006
  58. Inder TE, Hunt RW, Morley CJ, Coleman L, Stewart M, Doyle LW, et al. Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy. J Pediatr. 2004;145:835–837
  59. Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol. 2005;32:11–17
  60. Gunn AJ, Gluckman PD, Gunn TR. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics. 1998;102:885–892
  61. Lin ZL, Yu HM, Lin J, Chen SQ, Liang ZQ, Zhang ZY. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol. 2006;26:180–184
  62. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365:663–670
  63. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574–1584
  64. Gluckman P, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling after neonatal encephalopathy. Lancet. 2005;365:1619–1620
  65. Shankaran S, Laptook A, Ehrenkranz RA, Tyson JE, McDonald JS, Donovan EF. Reduction in death or moderate/severe disability by whole body hypothermia for hypoxic-ischemic encephalopathy (HIE). Pediatr Res. 2005;57:1548A
  66. Wyatt JS, Gluckman PD, Liu PL, Azzopardi D, Edwards AD, Ferriero DM, et al. The determinants of outcome after head cooling for neonatal encephalopathy. Pediatrics; in press
  67. Ambalavanan N, Carlo WA, Shankaran S, Bann CM, Emrich SL, Higgins RD, et al. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics. 2006;118:2084–2093
  68. The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy. Online. Available at: http://www.npeu.ox.ac.uk/Toby [last accessed 1 October 2006].
  69. neo.nEuro.network. HYPOTHERMIA trial. Online. Available at: http://www.neonatal-research [last accessed 20 September 2005].
  70. Evans K, Rigby AS, Hamilton P, Titchiner N, Hall DM. The relationships between neonatal encephalopathy and cerebral palsy: a cohort study. J Obstet Gynaecol. 2001;21:114–120
  71. Lawn J, Shibuya K, Stein C. No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ. 2005;83:409–417

PII: S1744-165X(07)00023-6

doi: 10.1016/j.siny.2007.01.022

Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 4 , Pages 303-310 , August 2007

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