Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 4 , Pages 239-240 , August 2007

Neuroprotection of the newborn: From bench to cribside

  • Géraldine Favrais
    • ,
  • Pierre Gressens

      Affiliations

    • Corresponding Author InformationCorresponding author. Inserm, U676, Hôpital Robert Debré, 48 Blvd Sérurier, F-759019 Paris, France. Tel.: +33 (0) 1 40 03 19 76; fax: +33 (0) 1 40 03 19 95.

References 

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  4. Finer NN, Craft A, Vaucher YE, Clark RH, Sola A. Postnatal steroids: short-term gain, long-term pain?. J Pediatr. 2000;137:9–13
  5. Gressens P, Rogido M, Paindaveine B, Sola A. The impact of neonatal intensive care practices on the developing brain. J Pediatr. 2002;140:646–653
  6. Grow J, Barks JD. Pathogenesis of hypoxic–ischemic cerebral injury in the term infant: current concepts. Clin Perinatol. 2002;29:585–602[v]
  7. Hagberg H. Mitochondrial impairment in the developing brain after hypoxia–ischemia. J Bioenerg Biomembr. 2004;36:369–373
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  9. McQuillen PS, Ferriero DM. Selective vulnerability in the developing central nervous system. Pediatr Neurol. 2004;30:227–235
  10. Mesples B, Plaisant F, Fontaine RH, Gressens P. Pathophysiology of neonatal brain lesions: lessons from animal models of excitotoxicity. Acta Paediatr. 2005;94:185–190
  11. Nelson KB, Grether JK. Causes of cerebral palsy. Curr Opin Pediatr. 1999;11:487–491
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  13. O'Shea TM, Doyle LW. Perinatal glucocorticoid therapy and neurodevelopmental outcome: an epidemiologic perspective. Semin Neonatol. 2001;6:293–307
  14. Shalak L, Perlman JM. Hypoxic–ischemic brain injury in the term infant-current concepts. Early Hum Dev. 2004;80:125–141
  15. Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection. Ment Retard Dev Disabil Res Rev. 2001;7:56–64
  16. Volpe JJ. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res. 2001;50:553–562
  17. Harding DR, Dhamrait S, Whitelaw A, Humphries SE, Marlow N, Montgomery HE. Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?. Pediatrics. 2004;114:941–947
  18. Kerk J, Dordelmann M, Bartels DB, Brinkhaus MJ, Dammann CE, Dork T, et al. Multiplex measurement of cytokine/receptor gene polymorphisms and interaction between interleukin-10 (-1082) genotype and chorioamnionitis in extreme preterm delivery. J Soc Gynecol Investig. 2006;13:350–356
  19. Dommergues MA, Patkai J, Renauld JC, Evrard P, Gressens P. Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium. Ann Neurol. 2000;47:54–63
  20. Eklind S, Mallard C, Leverin AL, Gilland E, Blomgren K, Mattsby-Baltzer I, et al. Bacterial endotoxin sensitizes the immature brain to hypoxic–ischaemic injury. Eur J Neurosci. 2001;13:1101–1106
  21. Favrais G, Schwendimann L, Gressens P, Lelièvre V. Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice. Neurobiol Dis. 2007;25(3):496–505
  22. Crowther CA, Hiller JE, Doyle LW, Haslam RR. Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. JAMA. 2003;290:2669–2676
  23. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365:663–670
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PII: S1744-165X(07)00025-X

doi: 10.1016/j.siny.2007.01.024

Seminars in Fetal & Neonatal Medicine
Volume 12, Issue 4 , Pages 239-240 , August 2007

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