Seminars in Fetal & Neonatal Medicine
Volume 13, Issue 1 , Pages 30-34 , February 2008

Current controversies in hypothermic neuroprotection

References 

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  2. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365(9460):663–670
  3. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy. N Engl J Med. 2005;353(15):1574–1584
  4. Edwards AD, Azzopardi DV. Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal Ed. 2006;91(2):F127–F131
  5. Kirpalani H, Barks J, Thorlund K, Guyatt G. Cooling for neonatal hypoxic–ischemic encephalopathy – is the answer in?. Pediatrics. 2007;120(5):1131–1132
  6. Higgins RD, Raju TN, Perlman J, et al. Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr. 2006;148(2):170–175
  7. Blackmon LR, Stark AR. Hypothermia: a neuroprotective therapy for neonatal hypoxic–ischemic encephalopathy. Pediatrics. 2006;117(3):942–948
  8. Gray J, Geva A, Zheng Z, Zupancic J. CoolSim: using industrial modeling techniques to examine the impact of selective head cooling in a model of perinatal regionalization. Pediatrics, in press.
  9. Gunn AJ, Gunn TR. The ‘pharmacology’ of neuronal rescue with cerebral hypothermia. Early Hum Dev. 1998;53(1):19–35
  10. Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol. 2005;32(1):18–24
  11. Leviton A, Nelson KB. Problems with definitions and classifications of newborn encephalopathy. Pediatr Neurol. 1992;8(2):85–90
  12. Wyatt JS, Gluckman PD, Liu PY, et al. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics. 2007;119(5):912–921
  13. Ambalavanan N, Carlo WA, Shankaran S, et al. Predicting outcomes of neonates diagnosed with hypoxemic–ischemic encephalopathy. Pediatrics. 2006;118(5):2084–2093
  14. Liu Y, Barks JD, Xu G, Silverstein FS. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke. 2004;35(6):1460–1465
  15. Jatana M, Singh I, Singh AK, Jenkins D. Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic–ischemic brain injury in neonatal rats. Pediatr Res. 2006;59(5):684–689
  16. Iwata O, Iwata S, Thornton JS, et al. ‘Therapeutic time window’ duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res. 2007;1154:173–180
  17. Inder TE, Hunt RW, Morley CJ, et al. Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic–ischemic encephalopathy. J Pediatr. 2004;145(6):835–837
  18. Rutherford MA, Azzopardi D, Whitelaw A, et al. Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic–ischemic encephalopathy. Pediatrics. 2005;116(4):1001–1006

PII: S1744-165X(07)00108-4

doi: 10.1016/j.siny.2007.09.004

Seminars in Fetal & Neonatal Medicine
Volume 13, Issue 1 , Pages 30-34 , February 2008

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