Seminars in Fetal & Neonatal Medicine
Volume 13, Issue 1 , Pages 35-43 , February 2008

Probiotics and other preventative strategies for necrotising enterocolitis

References 

  1. Deshpande G, Rao S, Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials. [see comment] Lancet. 2007;369:1614–1620
  2. Flidel-Rimon O, Branski D, Shinwell ES. The fear of necrotizing enterocolitis versus achieving optimal growth in preterm infants – an opinion. Acta Paediatr. 2006;95:1341–1344
  3. Embleton ND, Pang N, Cooke RJ. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants?. Pediatrics. 2001;107:270–273
  4. Kosloske AM, Musemeche CA. Necrotizing enterocolitis of the neonate. Clin Perinatol. 1989;16:97–111
  5. Kosloske AM. Pathogenesis and prevention of necrotizing enterocolitis: a hypothesis based on personal observation and a review of the literature. Pediatrics. 1984;74:1086–1092
  6. Neu J. The ‘myth’ of asphyxia and hypoxia–ischemia as primary causes of necrotizing enterocolitis. [comment] Biol Neonate. 2005;87:97–98
  7. Warner BB, Ryan AL, Seeger K, Leonard AC, Erwin CR, Warner BW. Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. [see comment] J Pediatr. 2007;150:358–363
  8. Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1–7
  9. Stoll BJ, Hansen NI, Adams-Chapman I, et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. [see comment] JAMA. 2004;292:2357–2365
  10. Bell EF. Preventing necrotizing enterocolitis: what works and how safe?. Pediatrics. 2005;115:173–174
  11. Dorling J, Kempley S, Leaf A. Feeding growth restricted preterm infants with abnormal antenatal Doppler results. Arch Dis Child Fetal Neonatal Ed. 2005;90:
  12. Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev. 2000;(2):CD000065;PMID: 10796110
  13. Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. [see comment] Lancet. 2001;357:979–988[Erratum appears in Lancet 2001; 358:156]
  14. Al-Sabbagh A, Moss S, Subhedar N. Neonatal necrotising enterocolitis and perinatal exposure to co-amoxyclav. Arch Dis Child Fetal Neonatal Ed. 2004;89:
  15. Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet. 2006;368:1271–1283
  16. Mally P, Golombek SG, Mishra R, et al. Association of necrotizing enterocolitis with elective packed red blood cell transfusions in stable, growing, premature neonates. Am J Perinatol. 2006;23:451–458
  17. Ledbetter DJ, Juul SE. Erythropoietin and the incidence of necrotizing enterocolitis in infants with very low birth weight. J Pediatr Surg. 2000;35:178–181
  18. Schmidt B, Davis P, Moddemann D, et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. [see comment] N Engl J Med. 2001;344:1966–1972
  19. Guillet R, Stoll BJ, Cotten CM, et al. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. [see comment] Pediatrics. 2006;117:
  20. Pietz J, Achanti B, Lilien L, Stepka EC, Mehta SK. Prevention of necrotizing enterocolitis in preterm infants: a 20-year experience. Pediatrics. 2007;119:e164–e170
  21. Patole SK, de Klerk N. Impact of standardised feeding regimens on incidence of neonatal necrotising enterocolitis: a systematic review and meta-analysis of observational studies. [see comment] Arch Dis Child Fetal Neonatal Ed. 2005;90:147–151
  22. Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. [Update of Cochrane Database Syst Rev 2000;(2):CD000503. PMID: 10796373] Cochrane Database Syst Rev. 2001;(3):CD000503;PMID: 11686962
  23. Bell EF, Warburton D, Stonestreet BS, Oh W. Effect of fluid administration on the development of symptomatic patent ductus arteriosus and congestive heart failure in premature infants. N Engl J Med. 1980;302:598–604
  24. Eibl MM, Wolf HM, Furnkranz H, Rosenkranz A. Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA–IgG feeding. N Engl J Med. 1988;319:1–7
  25. Foster J, Cole M. Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth-weight neonates. [Update of Cochrane Database Syst Rev 2004;(1):CD001816. PMID: 14973972] Cochrane Database Syst Rev. 2001;(3):CD001816;PMID: 11686997
  26. Lawrence G, Tudehope D, Baumann K, et al. Enteral human IgG for prevention of necrotising enterocolitis: a placebo-controlled, randomised trial. Lancet. 2001;357:2090–2094
  27. Tyson JE, Kennedy KA. Trophic feedings for parenterally fed infants. [Update of Cochrane Database Syst Rev 2000;(2):CD000504. PMID: 10796374] Cochrane Database Syst Rev. 2005;(3):CD000504;PMID: 16034854
  28. Berseth CL, Bisquera JA, Paje VU. Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants. [comment] Pediatrics. 2003;111:529–534
  29. Menon G, Boyle EM, Embleton ND, McIntosh N. Introduction of enteral feeds in preterm infants. [comment] Pediatrics. 2004;114:327–328
  30. Kennedy KA, Tyson JE, Chamnanvanakij S. Rapid versus slow rate of advancement of feedings for promoting growth and preventing necrotizing enterocolitis in parenterally fed low-birth-weight infants. Cochrane Database Syst Rev. 2000;(2):CD001241;PMID: 10796423
  31. Kennedy KA, Tyson JE, Chamnanvanikij S. Early versus delayed initiation of progressive enteral feedings for parenterally fed low birth weight or preterm infants. Cochrane Database Syst Rev. 2000;(2):CD001970;PMID: 10796276
  32. Available from: http://www.npeu.ox.ac.uk/adept/
  33. McGuire W, Anthony MY. Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. [see comment] Arch Dis Child Fetal Neonatal Ed. 2003;88:
  34. Schanler RJ, Lau C, Hurst NM, Smith EO. Randomized trial of donor human milk versus preterm formula as substitutes for mothers' own milk in the feeding of extremely premature infants. [see comment] Pediatrics. 2005;116:400–406
  35. Boyd CA, Quigley MA, Brocklehurst P. Donor breast milk versus infant formula for preterm infants: systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2007;92:
  36. Gessler P, Bischoff GA, Wiegand D, Essers B, Bossart W. Cytomegalovirus-associated necrotizing enterocolitis in a preterm twin after breastfeeding. J Perinatol. 2004;24:124–126
  37. Cooke RJ, Embleton ND. Feeding issues in preterm infants. Arch Dis Child. 2000;83:F215–F218
  38. Neu J, Roig JC, Meetze WH, et al. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr. 1997;131:691–699
  39. Poindexter BB, Ehrenkranz RA, Stoll BJ, et al. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics. 2004;113:1209–1215
  40. Tubman TR, Thompson SW, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. [Update of Cochrane Database Syst Rev 2001;(4):CD001457. PMID: 11687112] Cochrane Database Syst Rev. 2005;(1):CD001457;PMID: 15675878
  41. Amin HJ, Zamora SA, McMillan DD, et al. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. [see comment] J Pediatr. 2002;140:425–431
  42. Boehm G, Lidestri M, Casetta P, et al. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2002;86:
  43. Mollitt DL, String DL, Tepas JJ, Talbert JL. Does patient age or intestinal pathology influence the bacteria found in cases of necrotizing enterocolitis?. South Med J. 1991;84:879–882
  44. Boccia D, Stolfi I, Lana S, Moro ML. Nosocomial necrotising enterocolitis outbreaks: epidemiology and control measures. Eur J Pediatr. 2001;160:385–391
  45. Coates EW, Karlowicz MG, Croitoru DP, Buescher ES. Distinctive distribution of pathogens associated with peritonitis in neonates with focal intestinal perforation compared with necrotizing enterocolitis. Pediatrics. 2005;116:e241–e246
  46. Llanos AR, Moss ME, Pinzon MC, Dye T, Sinkin RA, Kendig JW. Epidemiology of neonatal necrotising enterocolitis: a population-based study. Paediatr Perinat Epidemiol. 2002;16:342–349
  47. Isaacs D Australasian Study Group for Neonatal Infections. A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units. Arch Dis Child Fetal Neonatal Ed. 2003;88:F89–F93
  48. Siu YK, Ng PC, Fung SC, et al. Double blind, randomised, placebo controlled study of oral vancomycin in prevention of necrotising enterocolitis in preterm, very low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1998;79:
  49. Kosloske AM, Ball WS, Umland E, Skipper B. Clostridial necrotizing enterocolitis. J Pediatr Surg. 1985;20:155–159
  50. Thomas DF, Fernie DS, Bayston R, Spitz L. Clostridial toxins in neonatal necrotising enterocolitis. Arch Dis Child. 1984;59:270–272
  51. de la Cochetiere MF, Piloquet H, des Robert C, Darmaun D, Galmiche JP, Roze JC. Early intestinal bacterial colonization and necrotizing enterocolitis in premature infants: the putative role of Clostridium. Pediatr Res. 2004;56:366–370
  52. Bury RG, Tudehope D. Enteral antibiotics for preventing necrotising enterocolitis in low birthweight or preterm infants. [Update of Cochrane Database Syst Rev 2001;(1):CD000405. PMID: 11279690] Cochrane Database Syst Rev. 2000;(2):CD000405;PMID: 10796202
  53. Boyle R, Nelson JS, Stonestreet BS, Peter G, Oh W. Alterations in stool flora resulting from oral kanamycin prophylaxis of necrotizing enterocolitis. J Pediatr. 1978;93:857–861
  54. Ng PC, Dear PR, Thomas DF. Oral vancomycin in prevention of necrotising enterocolitis. Arch Dis Child. 1988;63:1390–1393
  55. Raskind CH, Dembry LM, Gallagher PG. Vancomycin-resistant enterococcal bacteremia and necrotizing enterocolitis in a preterm neonate. Pediatr Infect Dis J. 2005;24:943–944
  56. Panigrahi P, Gupta S, Gewolb IH, Morris JG. Occurrence of necrotizing enterocolitis may be dependent on patterns of bacterial adherence and intestinal colonization: studies in Caco-2 tissue culture and weanling rabbit models. Pediatr Res. 1994;36:115–121
  57. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol. 1997;159:1739–1745
  58. Millar M, Wilks M, Costeloe K. Probiotics for preterm infants?. Arch Dis Child Fetal Neonatal Ed. 2003;88:
  59. Van Niel CW, Feudtner C, Garrison MM, Christakis DA. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. [see comment] Pediatrics. 2002;109:678–684
  60. Rautava S. Potential uses of probiotics in the neonate. Semin Fetal Neonatal Med. 2007;12:45–53
  61. Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 1997;76:F101–F107
  62. Costalos C, Skouteri V, Gounaris A, et al. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev. 2003;74:89–96
  63. Mohan R, Koebnick C, Schildt J, et al. Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm infants: a double-blind, placebo-controlled, randomized study. J Clin Microbiol. 2006;44:4025–4031
  64. Agarwal R, Sharma N, Chaudhry R, et al. Effects of oral Lactobacillus GG on enteric microflora in low-birth-weight neonates. J Pediatr Gastroenterol Nutr. 2003;36:397–402
  65. Manzoni P, Mostert M, Leonessa ML, et al. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis. 2006;42:1735–1742
  66. Hoyos AB. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis. 1999;3:197–202
  67. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate. 2002;82:103–108
  68. Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. [see comment] Pediatrics. 2005;115:1–4
  69. Bin-Nun A, Bromiker R, Wilschanski M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. [see comment] J Pediatr. 2005;147:192–196
  70. Kunz AN, Fairchok MP, Noel JM. Lactobacillus sepsis associated with probiotic therapy. Pediatrics. 2005;116:517–518
  71. Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr. 2004;38:457–458
  72. Thompson C, McCarter YS, Krause PJ, Herson VC. Lactobacillus acidophilus sepsis in a neonate. J Perinatol. 2001;21:258–260
  73. Hammerman C, Kaplan M. Probiotics and neonatal intestinal infection. Curr Opin Infect Dis. 2006;19:277–282
  74. Neu J, Douglas-Escobar M, Lopez M. Microbes and the developing gastrointestinal tract. Nutr Clin Pract. 2007;22:174–182
  75. Schmolzer G, Urlesberger B, Haim M, et al. Multi-modal approach to prophylaxis of necrotizing enterocolitis: clinical report and review of literature. Pediatr Surg Int. 2006;22:573–580
  76. Kuzma-O'Reilly B, Duenas ML, Greecher C, et al. Evaluation, development, and implementation of potentially better practices in neonatal intensive care nutrition. Pediatrics. 2003;111:e461–e470
  77. Patole S. Prevention of necrotising enterocolitis: year 2004 and beyond. J Matern Fetal Neonatal Med. 2005;17:69–80

PII: S1744-165X(07)00109-6

doi: 10.1016/j.siny.2007.09.003

Seminars in Fetal & Neonatal Medicine
Volume 13, Issue 1 , Pages 35-43 , February 2008