Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 3 , Pages 148-156, June 2010

Glucose-6-phosphate dehydrogenase deficiency and severe neonatal hyperbilirubinemia: a complexity of interactions between genes and environment

  • Michael Kaplan

      Affiliations

    • Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    • Faculty of Medicine of the Hebrew University, Jerusalem, Israel
    • Corresponding Author InformationCorresponding author. Department of Neonatology, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel. Tel.: +972 2 655 5643; fax: +972 2 655 5998.
    • ,
  • Cathy Hammerman

      Affiliations

    • Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    • Faculty of Medicine of the Hebrew University, Jerusalem, Israel

published online 30 November 2009.

Summary 

Glucose-6-phosphate dehydrogenase deficiency is a commonly occurring genetic condition, likely to be encountered today in virtually any corner of the globe. Sudden episodes of hemolysis associated with the condition may result in exponential increases in serum total bilirubin concentrations to levels at which bilirubin-induced neurologic damage may occur. The hyperbilirubinemia is the result of complex interactions between genes and environment. Neonatal screening programs coupled with parental and medical caretaker education may be successful in limiting the severity of disease.

Keywords: Bilirubin, Glucose-6-phosphate dehydrogenase deficiency, Hemolysis, Kernicterus, Screening test

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PII: S1744-165X(09)00107-3

doi:10.1016/j.siny.2009.10.007

Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 3 , Pages 148-156, June 2010

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