Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 3 , Pages 136-140 , June 2010

Enduring controversies in the management of hyperbilirubinemia in preterm neonates

  • Jon F. Watchko

      Affiliations

    • Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 412 641 1834; fax: +1 412 641 5313.
  • ,
  • M. Jeffrey Maisels

      Affiliations

    • Department of Pediatrics, Oakland University William Beaumont School of Medicine, Division of Neonatology, Beaumont Children's Hospital, Royal Oak, Michigan, USA

References 

  1. Jardine DS, Rogers K. Relationship of benzyl alcohol to kernicterus, intraventricular hemorrhage, and mortality in preterm infants. Pediatrics. 1989;83:153–160
  2. Pearlman MA, Gartner LM, Lee K, Morecki R, Horoupian DS. Absence of kernicterus in low-birth-weigth infants from 1971 through 1976: comparison with findings from 1966 and 1967. Pediatrics. 1978;62:460–464
  3. Watchko J, Claasen D. Kernicterus in premature infants: current prevalence and relationship to NICHD phototherapy study exchange criteria. Pediatrics. 1994;93:996–999
  4. Cashore WJ. Bilirubin and jaundice in the micropremie. Clin Perinatol. 2000;27:171–179
  5. Maisels MJ, Watchko JF. Treatment of jaundice in low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 2003;88:459–463
  6. Maisels MJ. Phototherapy – traditional and non-traditional. J Perinatol. 2001;21:S93–S97
  7. O'Shea TM, Dillard RG, Klinepeter KD, et al. Serum bilirubin levels, intracranial hemorrhage, and the risk of developmental problems in very low birth weight infants. Pediatrics. 1992;90:888–892
  8. Harris RC, Lucey JF, MacLean JR. Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. Pediatrics. 1958;21:pp. 875–3
  9. Gartner LM, Snyder RN, Chabon RS, Bernstein J. Kernicterus: high incidence in premature infants with low serum bilirubin concentrations. Pediatrics. 1970;45:906–917
  10. Sugama S, Soeda A, Eto Y. Magnetic resonance imaging in three children with kernicterus. Pediatr Neurol. 2001;25:328–331
  11. Okumura A, Kidokoro H, Shoji H, et al. Kernicterus in preterm infants. Pediatrics. 2009;123:e1052–e1058
  12. Bhutani VK, Johnson LH, Shapiro SM. Kernicterus in sick and preterm infants (1999–2002): a need for an effective preventive approach. Semin Perinatol. 2004;28:319–325
  13. van de Bor M, van Zeben-van der Aa TM, Verloove-Vanhorick SP, et al. Hyperbilirubinemia in very preterm infants and neurodevelopmental outcome at two years of age: results of a national collaborative survey. Pediatrics. 1989;83:915–920
  14. Scheidt PC, Mellitis ED, Hardy JB, Drage JS, Boggs TR. Toxicity to bilirubin in neonates: infant development during first year in relation to maximum neonatal serum bilirubin concentration. J Pediatr. 1977;91:292–297
  15. Naeye RL. Amniotic fluid infections, neonatal hyperbilirubinemia, and psychomotor impairment. Pediatrics. 1978;62:497–503
  16. Gkoltsiou K, Tzoufi M, Counsell S, Rutherford M, Cowan F. Serial brain MRI and ultrasound findings: relation to gestational age, bilirubin level, neonatal neurologic status and neurodevelopmental outcome in infants at risk of kernicterus. Early Hum Dev. 2008;84:829–838
  17. Oh W, Tyson JE, Fanaroff AA, et al. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics. 2003;112:773–779
  18. Govaert P, Lequin M, Swarte R, et al. Changes in globus pallidus with (pre)term kernicterus. Pediatrics. 2003;112:1256–1263
  19. Turkel SB, Guttenberg ME, Moynes DR, Hodgman JE. Lack of identifiable risk factors for kernicterus. Pediatrics. 1980;66:502–506
  20. Kim MH, Yoon JJ, Sher J, Brown AK. Lack of predictive indices in kernicterus: a comparison of clinical and pathologic factors in infants with and without kernicterus. Pediatrics. 1980;66:852–858
  21. Graziani LJ, Mitchell DG, Kornhauser M, et al. Neurodevelopment of preterm infants: neonatal neurosonographic and serum bilirubin studies. Pediatrics. 1992;89:229–234
  22. Macgregor D, Whitfield MF, Delcati D, Roland E. Bilirubin and kernicterus in infants <1000 grams birth weight: a follow-up study. Pediatr Res. 1989;25:257A
  23. Brown DR, Watchko JF, Sabo D. Neonatal sensorineural hearing loss associated with furosemide: a case–control study. Dev Med Child Neurol. 1991;33:816–823
  24. Hack M, Wilson-Costello D, Friedman H, Taylor GH, Schluchter M, Fanaroff AA. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g: 1992–1995. Arch Pediatr Adolesc Med. 2000;154:725–731
  25. Maisels MJ. Jaundice. In:  Avery GB,  Fletcher MA,  MacDonald MG editor. Neonatology: pathology and management of the newborn. Philadelphia: J.B. Lipincott; 1999;p. 765–819
  26. Rennie JM, Sehgal A, De A, Kendall GS, Cole TJ. Range of UK practice regarding thresholds for phototherapy and exchange transfusion in neonatal hyperbilirubinemia. Arch Dis Child Fetal Neonatal Ed. 2009;94:F323–F327
  27. Bryla DA. Development, design, and sample composition. Pediatrics. 1985;75(Suppl):387–441
  28. Brown AK, Kim MH, Wu PYK, Bryla DA. Efficacy of phototherapy in prevention and management of neonatal hyperbilirubinemia. Pediatrics. 1985;75(Suppl):393–441
  29. Lipsitz PJ, Gartner LM, Bryla DA. Neonatal and infant mortality in relation to phototherapy. Pediatrics. 1985;75(Suppl):422–441
  30. Ikonen RS, Kuusinen EJ, Janas MO, Koivkko MJ, Sorto AE. Possible etiologic factors in extensive periventricular leucomalacia of preterm infants. Acta Paediatr Scand. 1988;77:489–495
  31. Ikonen RS, Janas MO, Koivkko MJ, Laippala P, Kuusinen EJ. Hyperbilirubinemia, hypocarbia and periventricular leukomalacia in preterm infants: relationship to cerebral palsy. Acta Paediatr. 1992;81:802–807
  32. Trounce J, Shaw DE, Levine MI, Rutter N. Clinical risk factors and periventricular leucomalacia. Arch Dis Child. 1988;63:17–22
  33. Scheidt PC, Bryla DA, Nelson KB, Hirtz DG, Hoffman HJ. Phototherapy for neonatal hyperbilirubinemia. Six year follow-up of the NICHD clinical trial. Pediatrics. 1990;85:455–463
  34. Scheidt PC, Graubard BI, Nelson KB, et al. Intelligence at six years in relation to neonatal bilirubin level: follow-up of the National Institute of Child Health and Human Development Clinical Trial of Phototherapy. Pediatrics. 1991;87:797–805
  35. Morris BH, Oh W, Tyson JE, Stevenson DK, et al. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008;359:1885–1896
  36. Vreman HJ, Wong RJ, Stevenson DK. Phototherapy: current methods and future directions. Semin Perinatol. 2004;28:326–333
  37. Wennberg RP, Ahlfors CE, Bhutani VK, Johnson LH, Shapiro SM. Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns. Pediatrics. 2006;117:474–485
  38. McDonagh AF, Maisels MJ. Bilirubin unbound: déjà vu all over again. Pediatrics. 2006;117:523–525
  39. Cashore WJ, Oh W. Unbound bilirubin and kernicterus in low birthweight infants. Pediatrics. 1982;69:481–485
  40. Nakamura H, Yonetani M, Uetani Y, Funato M, Lee Y. Determination of serum unbound bilirubin for prediction of kernicterus in low birth weight infants. Acta Paediatr Jpn. 1992;54:642–647
  41. Funato M, Tamai H, Shimada S, Nakamura H. Vigintiphobia, unbound bilirubin, and auditory brainstem responses. Pediatrics. 1994;93:50–53
  42. Amin SB, Ahlfors CE, Orlando MS, Dalzell LE, Merle KS, Guillet R. Bilirubin and serial auditory brainstem responses in premature infants. Pediatrics. 2001;107:664–670
  43. Daood MJ, McDonagh AF, Watchko JF. Calculated free bilirubin levels and neurotoxicity. J Perinatol. 2009;29:S14–S19
  44. Ahlfors CE. Criteria for exchange transfusion in jaundiced newborns. Pediatrics. 1994;93:488–494
  45. Cashore WJ. Free bilirubin concentrations and bilirubin-binding affinity in term and preterm infants. J Pediatr. 1980;96:521–527
  46. Cashore WJ, Oh W, Brodersen R. Reserve albumin and bilirubin toxicity index in infant serum. Acta Paediatr Scand. 1983;72:415–419
  47. Ebbesen F, Brodersen R. Risk of bilirubin acid precipitation in preterm infants with respiratory distress syndrome: considerations of blood/brain bilirubin transfer equilibrium. Early Hum Dev. 1982;6:341–355
  48. Esbjorner E. Albumin binding properties in relation to bilirubin and albumin concentrations during the first week of life. Acta Paediatr Scand. 1991;80:400–405
  49. Ebbsen F, Nyboe J. Postnatal changes in the ability of plasma albumin to bind bilirubin. Acta Paediatr Scand. 1983;72:665–670
  50. Bender GJ, Cashore WJ, Oh W. Ontogeny of bilirubin-dinding capacity and the effect of clinical status in premature infants born at less than 1300 grams. Pediatrics. 2007;120:1067–1073
  51. Hulzebos CV, van Imhoff DE, Bos AF, Ahlfors CE, Verkade HJ, Dijk PH. Usefulness of the bilirubin/albumin ratio for predicting bilirubin-induced neurotoxicity in premature infants. Arch Dis Child Fetal Neonatal Ed. 2008;93:F384–F388
  52. Wennberg RP. Cellular basis of bilirubin toxicity. NY State J Med. 1991;91:493–496
  53. Watchko JF. Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolec Med. 2006;8:513–529

PII: S1744-165X(09)00120-6

doi: 10.1016/j.siny.2009.12.003

Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 3 , Pages 136-140 , June 2010