Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 4 , Pages 223-229, August 2010

Hyperoxia-derived lung damage in preterm infants

Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, 333 Cedar Street, LCI 401B, New Haven, CT 06520-8064, USA

published online 30 April 2010.

Summary 

Hyperoxia-induced lung injury is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. This review highlights the mechanistic aspects of inflammation, vascular leak and cell death. The focus will be on agents that contribute to hyperoxia-induced lung injury in developmentally appropriate animal models, and those that have been detected in human premature neonates.

Keywords: Cell death, Cytokines, Oxidants, Oxygen, Pulmonary

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PII: S1744-165X(10)00033-8

doi:10.1016/j.siny.2010.03.009

Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 4 , Pages 223-229, August 2010

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