Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 4 , Pages 191-195 , August 2010

Maturation of the antioxidant system and the effects on preterm birth

  • Jonathan M. Davis

      Affiliations

    • Tufts University School of Medicine, Boston, Massachusetts, USA
    • Corresponding Author InformationCorresponding author. Present Address: Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA. Tel.: +1 617 636 5322; fax: +1 617 636 1456.
    • ,
  • Richard L. Auten

      Affiliations

    • Duke University School of Medicine, Durham, North Carolina, USA

References 

  1. Auten RL, Davis JM. Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatr Res. 2009;66:121–127
  2. Frank L, Groseclose EE. Preparation for birth into an O2-rich environment: the antioxidant enzymes in the developing rabbit lung. Pediatr Res. 1984;18:240–244
  3. Nozik-Grayck E, Dieterle CS, Piantadosi CA, Enghild JJ, Oury TD. Secretion of extracellular superoxide dismutase in neonatal lungs. Am J Physiol Lung Cell Mol Physiol. 2000;279:L977–L984
  4. Auten RL, O’Reilly MA, Oury TD, Nozik-Grayck E, Whorton MH. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006;290:L32–L40
  5. Matalon S, Holm BA, Baker RR, Whitfield MK, Freeman BA. Characterization of antioxidant activities of pulmonary surfactant mixtures. Biochim Biophys Acta. 1990;1035:121–127
  6. Land SC. Oxygen-sensing pathways and the development of mammalian gas exchange. Redox Rep. 2003;8:325–340
  7. Qanungo S, Mukherjea M. Ontogenic profile of some antioxidants and lipid peroxidation in human placental and fetal tissues. Mol Cell Biochem. 2000;215:11–19
  8. Boggess KA, Kay HH, Crapo JD, Moore WF, Suliman HB, Oury TD. Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. Am J Obstet Gynecol. 2000;183:199–205
  9. Gharesi-Fard B, Zolghadri J, Kamali-Sarvestani E. Proteome differences of placenta between pre-eclampsia and normal pregnancy. Placenta. 2010;31:121–125
  10. Patil SB, Kodliwadmath MV, Kodliwadmath M. Lipid peroxidation and antioxidant activity in complicated pregnancies. Clin Exp Obstet Gynecol. 2009;36:110–112
  11. Kontic-Vucinic O, Terzic M, Radunovic N. The role of antioxidant vitamins in hypertensive disorders of pregnancy. J Perinat Med. 2008;36:282–290
  12. Llanos MN, Ronco AM. Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities. Reprod Toxicol. 2009;27:88–92
  13. Hracsko Z, Hermesz E, Ferencz A, et al. Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation. In Vivo. 2009;23:727–732
  14. Auten RL, White CW. Oxidative and nitrosative stress and bronchopulmonary dysplasia. In:  Abman SH editors. Bronchopulmonary dysplasia. New York: Informa Health Care; 2009;
  15. van der Vliet A. NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med. 2008;44:938–955
  16. Auten RL, Mason SN, Auten KM, Brahmajothi M. Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L134–L142
  17. Saito Y, Geisen P, Uppal A, Hartnett ME. Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Mol Vis. 2007;13:840–853
  18. Lurie S, Matas Z, Boaz M, Fux A, Golan A, Sadan O. Different degrees of fetal oxidative stress in elective and emergent cesarean section. Neonatology. 2007;92:111–115
  19. Georgeson GD, Szony BJ, Streitman K, et al. Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section. Eur J Obstet Gynecol Reprod Biol. 2002;103:136–139
  20. Nassi N, Ponziani V, Becatti M, Galvan P, Donzelli G. Anti-oxidant enzymes and related elements in term and preterm newborns. Pediatr Int. 2009;51:183–187
  21. Darlow BA, Austin NC. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst Rev. 2003;CD003312
  22. Than NG, Romero R, Tarca AL, et al. Mitochondrial manganese superoxide dismutase mRNA expression in human chorioamniotic membranes and its association with labor, inflammation, and infection. J Matern Fetal Neonatal Med. 2009;22:1000–1013
  23. Schmatz M, Madan J, Marino T, Davis JM. Maternal obesity: the interplay between inflammation, mother and fetus. J Perinatol. 2009 Nov 12;[Epub ahead of print]
  24. Roberts VH, Smith J, McLea SA, Heizer AB, Richardson JL, Myatt L. Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta. Placenta. 2009;30:169–175
  25. Dheen ST, Tay SS, Boran J, et al. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Curr Med Chem. 2009;16:2345–2354
  26. Arita Y, Harkness SH, Kazzaz J, et al. Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006;290:L978–L986
  27. Asikainen TM, Heikkila P, Kaarteenaho-Wiik R, Kinnula VL, Raivio KO. Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension. Pediatr Pulmonol. 2001;32:193–200
  28. Copin JC, Gasche Y, Chan PH. Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase. Free Radic Biol Med. 2000;28:1571–1576
  29. Davis JM, Parad RB, Michele T, Allred E, Price A, Rosenfeld W. Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase. Pediatrics. 2003;111:469–476
  30. Morton RL, Das KC, Guo XL, Ikle DN, White CW. Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia. Am J Physiol. 1999;276:L64–L74
  31. Vento M, Aguar M, Escobar J, et al. Antenatal steroids and antioxidant enzyme activity in preterm infants: influence of gender and timing. Antioxid Redox Signal. 2009;11:2945–2955
  32. Wispe JR, Warner BB, Clark JC, et al. Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury. J Biol Chem. 1992;267:23937–23941
  33. Ahmed MN, Suliman HB, Folz RJ, et al. Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. Am J Respir Crit Care Med. 2003;167:400–405
  34. Chang LY, Subramaniam M, Yoder BA, et al. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2003;167:57–64
  35. te Braake FW, Schierbeek H, Vermes A, Huijmans JG, van Goudoever JB. High-dose cysteine administration does not increase synthesis of the antioxidant glutathione preterm infants. Pediatrics. 2009;124:e978–e984
  36. Shah MD, Shah SR. Nutrient deficiencies in the premature infant. Pediatr Clin North Am. 2009;56:1069–1083
  37. Debier C, Larondelle Y. Vitamins A and E: metabolism, roles and transfer to offspring. Br J Nutr. 2005;93:153–174
  38. Darlow BA, Graham PJ. Vitamin A supplementation to prevent mortality and short and long-term morbidity in very low birthweight infants. Cochrane Database Syst Rev. 2007;CD000501
  39. Ambalavanan N, Tyson JE, Kennedy KA, et al. Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months. Pediatrics. 2005;115:e249–e254
  40. Baydas G, Karatas F, Gursu MF, et al. Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status. Arch Med Res. 2002;33:276–280
  41. Brion LP, Bell EF, Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2003;CD003665
  42. Berger TM, Frei B, Rifai N, et al. Early high dose antioxidant vitamins do not prevent bronchopulmonary dysplasia in premature baboons exposed to prolonged hyperoxia: a pilot study. Pediatr Res. 1998;43:719–726
  43. Das KC. Thioredoxin system in premature and newborn biology. Antioxid Redox Signal. 2004;6:177–184
  44. Grigg J, Barber A, Silverman M. Bronchoalveolar lavage fluid glutathione in intubated premature infants. Arch Dis Child. 1993;69:49–51
  45. Patel A, Lakshminrusimha S, Ryan RM, et al. Exposure to supplemental oxygen downregulates antioxidant enzymes and increases pulmonary arterial contractility in premature lambs. Neonatology. 2009;96:182–192
  46. Collard KJ. Iron homeostasis in the neonate. Pediatrics. 2009;123:1208–1216
  47. Lindeman JH, Lentjes EG, van Zoeren-Grobben D, Berger HM. Postnatal changes in plasma ceruloplasmin and transferrin antioxidant activities in preterm babies. Biol Neonate. 2000;78:73–76
  48. Ledo A, Arduini A, Asensi MA, et al. Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants. Am J Clin Nutr. 2009;89:210–215
  49. Hoang VM, Foulk R, Clauser K, Burlingame A, Gibson BW, Fisher SJ. Functional proteomics: examining the effects of hypoxia on the cytotrophoblast protein repertoire. Biochemistry. 2001;40:4077–4086

PII: S1744-165X(10)00034-X

doi: 10.1016/j.siny.2010.04.001

Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 4 , Pages 191-195 , August 2010

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