« Previous
Next »
Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 5
, Pages 253-260
, October 2010
Potential biomarkers for hypoxic–ischemic encephalopathy
References
- . The pathogenesis of preterm brain injury. In: Stevenson DK, Benitz WE, Sunshine P, Druzin ML editor. Fetal and neonatal brain injury: mechanisms, management, and the risks of practice. 4th ed.. Cambridge: Cambridge University Press; 2009;p. 48–57
- . Timing of injury in the fetus and neonate. Curr Opin Obstet Gynecol. 2008;20:175–181
- Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. Br Med J. 2010;340:c363
- Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy. N Engl J Med. 2005;353:1574–1584
- Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol. 2005;32:11–17
- Selective head cooling with mild systemic hypothermia to improve neurodevelopmental outcome following neonatal encephalopathy. Lancet. 2005;365(9460):663–670
- . Hypothermic neuroprotection. NeuroRx. 2006;3:154–169
- . Mechanisms of delayed cell death following hypoxic–ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Brain Res Mol Brain Res. 1995;29:1–14
- . Delayed cerebral atrophy following moderate hypoxia–ischemia in the immature rat. Dev Neurosci. 2001;23:180–185
- Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev Med Child Neurol. 1997;39:718–725
- The intrapartum deceleration in center stage: a physiological approach to interpretation of fetal heart rate changes in labor. Am J Obstet Gynecol. 2007;197:236.e1–236.e11
- . Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am J Obstet Gynecol. 1997;176(1 Pt 1):18–27
- . Brief repeated umbilical cord occlusions cause sustained cytotoxic cerebral edema and focal infarcts in near-term fetal lambs. Pediatr Res. 1997;41:96–104
- . A systematic review of the role of intrapartum hypoxia–ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol. 2008;199:587–595
- . A template for defining a causal relation between acute intrapartum events and cerebral palsy: international consensus statement. Br Med J. 1999;319:1054–1059
- Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet. 2003;361(9359):736–742
- “Therapeutic time window” duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res. 2007;1154:173–180
- . Mitochondria-targeted cytoprotective peptides for ischemia–reperfusion injury. Antioxid Redox Signal. 2008;10:601–619
- . Uncertain value of electronic fetal monitoring in predicting cerebral palsy. N Engl J Med. 1996;334:613–618
- Fetal heart rate patterns in neonatal hypoxic–ischemic encephalopathy: relationship with early cerebral activity and neurodevelopmental outcome. Am J Perinatol. 2009;26:605–612
- . Threshold of metabolic acidosis associated with neonatal encephalopathy in the term newborn. J Matern Fetal Neonatal Med. 2005;18:381–385
- . Threshold of metabolic acidosis associated with newborn complications. Am J Obstet Gynecol. 1997;177:1391–1394
- . Pathophysiology of asphyxia. In: Levene M, Chervenack FA editor. Fetal and neonatal neurology and neurosurgery. 4th ed.. Philadelphia: Churchill Livingstone/Elsevier; 2009;p. 472–490
- . Glycogen reserves and their changes at birth and in anoxia. Br Med Bull. 1961;17:137–143
- . The importance of cardiac glycogen for the maintenance of life in foetal lambs and newborn animals during anoxia. J Physiol. 1959;146:516–538
- The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep. J Appl Physiol. 2007;103:1311–1317
- Outcome of term infants using apgar scores at 10 minutes following hypoxic–ischemic encephalopathy. Pediatrics. 2009;124:1619–1626
- New markers of neonatal neurology. J Matern Fetal Neonatal Med. 2009;22(Suppl. 3):57–61
- Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr Neurol. 2009;40:215–216
- Amniotic fluid S100B protein and erythropoietin in pregnancies at risk for fetal hypoxia. Eur J Obstet Gynecol Reprod Biol. 2009;142:115–118
- Increased levels of serum S100B protein in critically ill patients without brain injury. Shock. 2006;26:20–24
- Increased maternal/fetal blood S100B levels following systemic endotoxin administration and periventricular white matter injury in preterm fetal sheep. Reprod Sci. 2009;16:758–766
- The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J Perinat Med. 2007;35:385–393
- Effects of mode of delivery on maternal–neonatal plasma antioxidant status and on protein S100B serum concentrations. Scand J Clin Lab Invest. 2006;66:733–742
- . A glial-derived protein, S100B, in neonates and infants with congenital heart disease: evidence for preexisting neurologic injury. Anesth Analg. 2002;95:889–892table of contents
- A single course of antenatal betamethasone reduces neurotrophic factor S100B concentration in the hippocampus and serum in the neonatal rat. Brain Res Dev Brain Res. 2005;159:113–118
- S100B levels in the cerebrospinal fluid of rats are sex and anaesthetic dependent. Clin Exp Pharmacol Physiol. 2007;34:1126–1130
- S100B protein concentrations in cord blood: correlations with gestational age in term and preterm deliveries. Clin Chem. 2000;46:998–1000
- Pediatric concentrations of S100B protein in blood: age- and sex-related changes. Clin Chem. 2003;49(6 Pt 1):967–970
- Expression in the placenta of neuronal markers for perinatal brain damage. Pediatr Res. 2002;51:492–496
- . Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976;33:696–705
- Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics. 2007;119:912–921
- . Early biochemical indicators of hypoxic–ischemic encephalopathy after birth asphyxia. Pediatr Res. 2001;49:502–506
- . Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia. Pediatr Res. 2003;54:270–275
- . S100 protein in serum as a prognostic marker for cerebral injury in term newborn infants with hypoxic ischemic encephalopathy. Pediatr Res. 2004;55:406–412
- . S100B protein related neonatal hypoxia. Arq Neuropsiquiatr. 2006;64:24–29
- Kinetics of serum S100B in newborns with intracranial lesions. Pediatr Int. 2008;50:17–22
- Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term. Front Biosci (Elite Ed). 2009;1:560–567
- Perinatal asphyxia in preterm neonates leads to serum changes in protein S-100 and neuron specific enolase. Curr Neurovasc Res. 2009;6:110–116
- . Acute hypoxia increases S100beta protein in association with blood flow redistribution away from peripheral circulations in fetal sheep. Pediatr Res. 2005;58:179–184
- Correlation of neuron-specific enolase and S100B with histological cerebral damage in fetal sheep after severe asphyxia. Brain Res. 2004;1018:136–140
- Serum levels of S100B, S100A1B and S100BB are all related to outcome after severe traumatic brain injury. Acta Neurochir (Wien). 2008;150:221–227discussion 227
- Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg. 2005;103(1 Suppl.):61–68
- . Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics. 2003;111:351–357
- Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349–1358
- . Early EEG findings in hypoxic–ischemic encephalopathy predict outcomes at 2 years. Pediatrics. 2009;124:e459–e467
- . Neonatal electroencephalography during the first twenty-four hours of life in full-term newborn infants. Neuropediatrics. 1986;17:11–18
- Fetal heart rate variability and brainstem injury after asphyxia in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2004;287:R925–R933
- . Neurosteroids in the fetus and neonate: potential protective role in compromised pregnancies. Neurochem Int. 2008;52:602–610
- . Fetal hypoxia insults and patterns of brain injury: insights from animal models. Clin Perinatol. 2009;36:579–593
- . Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep. J Physiol. 2006;572:141–154
- Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1569–R1576
- . Suppression of post hypoxic–ischemic EEG transients with dizocilpine is associated with partial striatal protection in the preterm fetal sheep. Neuropharmacology. 2006;50:491–503
- . Controversies regarding neonatal seizure recognition. Epileptic Disord. 2002;4:139–158
- Partial neuroprotection with low-dose infusion of the 2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. Neuropharmacology. 2008;55:166–174
- . Differential effects of hypothermia on early and late epileptiform events after severe hypoxia in preterm fetal sheep. J Neurophysiol. 2007;97:572–578
- . Endogenous alpha(2)-adrenergic receptor-mediated neuroprotection after severe hypoxia in preterm fetal sheep. Neuroscience. 2006;142:615–628
- . Transient NMDA receptor-mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep. Exp Physiol. 2006;91:423–429
- . Physiological significance of sharp wave transients on EEG recordings of healthy pre-term and full-term neonates. Electroencephalogr Clin Neurophysiol. 1994;90:179–185
- . Positive temporal sharp waves in electroencephalograms of the premature newborn. Neurophysiol Clin. 1996;26:350–362
- . The use of the EEG to predict outcome in premature infants with positive sharp waves. Clin Electroencephalogr. 1994;25:127–135
- Abnormal sharp transients on electroencephalograms in preterm infants with periventricular leukomalacia. J Pediatr. 2003;143:26–30
- . Age dependence of NMDA receptor involvement in epileptiform activity in rat hippocampal slices. Epilepsy Res. 1996;23:105–113
- Acute and chronic increases in excitability in rat hippocampal slices after perinatal hypoxia In vivo. J Neurophysiol. 1998;79:73–81
- . Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev. 2001;81:1065–1096
- . Compromised metabolic recovery following spontaneous spreading depression in the penumbra. Brain Res. 2004;999:167–174
- . Power spectral analysis of two-channel EEG in hypoxic–ischaemic encephalopathy. Early Hum Dev. 2007;83:379–383
- The effect of frequency band on quantitative EEG measures in neonates with hypoxic–ischaemic encephalopathy. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:717–721
- Scaling exponents of EEG are related to the temporal process of the therapeutic hypothermia following ischemic brain injury. Conf Proc IEEE Eng Med Biol Soc. 2009;1:2192–2195
- . Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia–ischemia in piglets. J Appl Physiol. 2009;106:1506–1512
- . Magnetic resonance spectroscopy in neonatal hypoxic–ischaemic insults. Childs Nerv Syst. 2001;17:145–149
- . Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls. Neonatology. 2008;94:237–244
- . Bench to bedside strategies for optimizing neuroprotection following perinatal hypoxia–ischaemia in high and low resource settings. Early Hum Dev. 2007;83:801–811
- Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet. 1984;2(8399):366–370
- Prognosis of newborn infants with hypoxic–ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1989;25:445–451
- Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia. Pediatr Res. 1996;40:749–758
- Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics. 2010;125:e382–e395
- . Secondary energy failure after cerebral hypoxia–ischemia in the immature rat. J Cereb Blood Flow Metab. 2004;24:1090–1097
- . Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia–ischemia prognosticates outcome in the newborn piglet. J Neurochem. 2008;107:1027–1035
- Use of mitochondrial inhibitors to demonstrate that cytochrome oxidase near-infrared spectroscopy can measure mitochondrial dysfunction noninvasively in the brain. J Cereb Blood Flow Metab. 1999;19:27–38
- Changes in human fetal cerebral hemoglobin concentration and oxygenation during labor measured by near-infrared spectroscopy. Am J Obstet Gynecol. 1992;166:1369–1373
- . Brain monitoring in neonates. Early Hum Dev. 2009;85:77–84
- . Is near-infrared spectroscopy living up to its promises?. Semin Fetal Neonatal Med. 2006;11:498–502
- . Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia–ischaemia in the newborn pig. Exp Brain Res. 2004;156:20–26
- . Post-hypoxic hypoperfusion is associated with suppression of cerebral metabolism and increased tissue oxygenation in near-term fetal sheep. J Physiol. 2006;572:131–139
- Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic–ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study. Pediatr Res. 2009;65:181–187
- . Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997;99:248–256
PII: S1744-165X(10)00043-0
doi: 10.1016/j.siny.2010.05.007
© 2010 Elsevier Ltd. All rights reserved.
« Previous
Next »
Seminars in Fetal & Neonatal Medicine
Volume 15, Issue 5
, Pages 253-260
, October 2010
