Have outcomes following extremely preterm birth improved over time?

  • Jeanie LY. Cheong
    Correspondence
    Corresponding author. Level 7, Newborn Research, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC, 3052, Australia.
    Affiliations
    Level 7, Newborn Research, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC, 3052, Australia

    Victorian Infant Brain Studies, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, VIC, 3052, Australia

    Level 7, Dept of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC, 3052, Australia
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  • Alicia J. Spittle
    Affiliations
    Department of Physiotherapy, University of Melbourne, Grattan St, Parkville, VIC, 3052, Australia

    Victorian Infant Brain Studies, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, VIC, 3052, Australia
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  • Alice C. Burnett
    Affiliations
    Victorian Infant Brain Studies, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, VIC, 3052, Australia

    Dept of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia
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  • Peter J. Anderson
    Affiliations
    Victorian Infant Brain Studies, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, VIC, 3052, Australia

    Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Room 537, 18 Innovation Walk, Clayton Campus, Clayton, VIC, 3800, Australia
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  • Lex W. Doyle
    Affiliations
    Victorian Infant Brain Studies, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, VIC, 3052, Australia

    Level 7, Dept of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC, 3052, Australia

    Dept of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia
    Search for articles by this author

      Abstract

      Increased survival of infants born preterm, especially those born extremely preterm (<28 weeks’ gestation), has meant that more are reaching later childhood and adulthood. As preterm birth is associated with a higher risk of neurodevelopmental deficits, the aim of this review was to determine whether or not the advances in perinatal care that led to improved survival have also had a positive impact on long-term neurodevelopment. Studies examining temporal changes in neurodevelopment are limited, and only from high-income countries. However, based on available published data, there is no definite trend of improved neurodevelopment at school age for neurosensory, cognitive, academic achievement, motor or executive function with time. Cerebral palsy rates, however, may be decreasing. More research is needed into the potential contributors for the trends observed, and also for other outcomes such as mental health and behavior.

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