Placental tissue stem cells and their role in neonatal diseases

  • Andreas Damianos
    Correspondence
    Corresponding author. Division of Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 7009, Cincinnati, OH, 45229, USA.
    Affiliations
    Division of Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
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  • Kui Xu
    Affiliations
    Center for Lung Regenerative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
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  • Gregory T. Kalin
    Affiliations
    Center for Lung Regenerative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
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  • Vladimir V. Kalinichenko
    Correspondence
    Corresponding author. Division of Neonatology and Pulmonary Biology, Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 7009, Cincinnati, OH, 45229, USA.
    Affiliations
    Division of Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

    Center for Lung Regenerative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

    Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
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Published:December 20, 2021DOI:https://doi.org/10.1016/j.siny.2021.101322

      Abstract

      Neonatal diseases such as hypoxic ischemic encephalopathy, diseases of prematurity and congenital disorders carry increased morbidity and mortality. Despite technological advancements, their incidence remains largely unabated. Stem cell (SC) interventions are novel therapies in the neonatal world. In pre-clinical models of neonatal diseases, SC applications have shown encouraging results. SC sources vary, with the bone marrow being the most utilized. However, the ability to harvest bone marrow SCs from neonates is limited. Placental-tissue derived SCs (PTSCs), provide an alternative and highly attractive source. Human placentas, the cornerstone of fetal survival, are abundant with such cells. Comparing to adult pools, PTSCs exhibit increased potency, decreased immunogenicity and stronger anti-inflammatory effects. Several types of PTSCs have been identified, with mesenchymal stem cells being the most utilized population. This review will focus on PTSCs and their pre-clinical and clinical applications in neonatology.

      Keywords

      Abbreviations:

      SC (stem cell), PTSC (placental-tissue derived stem cell), MSC (mesenchymal stromal/stem cell), ESC (epithelial stem cell), HPC (hematopoetic progenitor cell), HSC (hematopoetic stem cell), EPC (endothelial progenitor cell), ECFC (endothelial colony forming cell), UC (umbilical cord), UCB (umbilical cord blood), MNC (mononuclear cell), DMSC (decidua mesenchymal stromal/stem cell), CMSC (chorionic mesenchymal stromal/stem cell), AMSC (amniotic membrane mesenchymal stromal/stem cells), AESC (amniotic epithelial stem cell), AFMSC (amniotic fluid membrane mesenchymal stromal/stem cell), WJMSC (Wharton's jelly mesenchymal stromal/stem cell), CPC (cardiac progenitor cell), EV (extracellular vehicles), AC (amnion cell), BPD (bronchopulmonary dysplasia), CDH (congenital diaphragmatic hernia), CHD (congenital heart disease), HLHS (hypoplastic left heart syndrome), HIE (hypoxic ischemic encephalopathy), IVH (intraventricular hemorhage), MMC (meningomyelocele), NEC (necrotizing enterocolitis), TRASCET (transamniotic stem cell therapy)
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