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Persistent pulmonary hypertension of the newborn: Historical perspectives

  • Steven M. Donn
    Affiliations
    Division of Neonatal-Perinatal Medicine, Department of Pediatrics, C.S. Mott Children's Hospital, Michigan Medicine, University of Michigan, 8-621 C.S. Mott Children's Hospital, 1540 E. Hospital Drive, SPC 4254, Ann Arbor, MI, 48109-4254, USA
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Published:February 13, 2022DOI:https://doi.org/10.1016/j.siny.2022.101323

      Abstract

      For many decades, persistent pulmonary hypertension of the newborn (PPHN) remained a baffling disorder, often confused with cyanotic congenital heart disease, with a very high mortality. Originally described as a condition characterized by clear lung fields and profound hypoxemia, modern diagnostic techniques and novel therapeutics have improved the outcomes of affected newborns. This paper will review the historical aspects of PPHN and enable the reader to see how far we have come but also how far we have to go in conquering this unique disorder.

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